Evidence map›Paper›PMID 26684170›Full record

ArticleJournal of diabetes and its complications2016

The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes.

Tina Costacou, Trevor J Orchard

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Article in Journal of diabetes and its complications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tina CostacouDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address: CostacouT@edc.pitt.edu.
Trevor J OrchardDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
University of Pittsburgh · US

Funding

Epidemiology of Diabetes Complications (EDC) Phase II: renewalR37DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ORCHARD, TREVOR J. · 2009 to 2018
$6.5M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
NIDDK NIH HHS DK34818NIDDK NIH HHS R01 DK034818NIDDK NIH HHS R37 DK034818
6 · The paper itself

Abstract

aimsThe Haptoglobin (HP) 2-2 genotype increases cardiovascular diabetes complication incidence. In type 1 diabetes, HP 2-2 also predicts declining kidney function and end-stage renal disease. We investigated whether HP 2-2 predisposes to cardio-renal mortality, while considering other causes of death as competing risks.

methodsIndividuals with type 1 diabetes and HP data available (n=486; mean baseline age, 27 and duration, 19 years) were selected for study. Vital status was assessed as of 8/31/2014. The underlying cause of death was determined and classified based on standardized procedures.

resultsDuring 25 years of follow-up, 79 (16.3%) cardio-renal deaths and 43 (8.8%) deaths related to other causes occurred. Although total mortality did not differ by HP (25.4% with HP 1 versus 24.6% with HP 2-2, p=0.84), a greater proportion of HP 2-2 carriers exhibited a cardio-renal death (19.0 versus 14.2, p=0.05). In time-to-event analyses, HP 2-2 was associated with a statistically significant increase of the sub-distribution hazard ratio for cardio-renal mortality (HR=1.64, p=0.03), although this effect was somewhat attenuated after multivariable adjustment (HR=1.58, p=0.05).

conclusionsOur results suggest that in addition to predicting the incidence of cardio-renal complications, HP 2-2 also increases susceptibility for cardio-renal mortality in type 1 diabetes. These findings require validation in other cohorts.

Indexed as

AdolescentAdultDiabetes Mellitus, Type 1Diabetic AngiopathiesDiabetic NephropathiesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenotypeHaptoglobinsHumansKidney Failure, ChronicMalePrognosisYoung AdultHaptoglobinsCardiovascular mortalityCompeting riskHaptoglobin genotypeKidney disease mortalityMortalityType 1 diabetes

Identifiers

PMID26684170
PMCPMC4761325
OpenAlexW2176489049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.