ArticleJournal of pediatric rehabilitation medicine2015
Increased brain activation during working memory processing after pediatric mild traumatic brain injury (mTBI).
Article in Journal of pediatric rehabilitation medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury.Frontiers in neuroscience · 2026Pooled it
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Mild Jugular Compression Collar Ameliorated Changes in Brain Activation of Working Memory after One Soccer Season in Female High School Athletes.Journal of neurotrauma · 2018Trial
- Cognitive Outcomes Following Paediatric Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Studies up to 2025.Neuropsychology review · 2026Review
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Review
- Working Memory Recovery in Adolescents with Concussion: Longitudinal fMRI Study.Journal of clinical medicine · 2024Article
- Exploring oculomotor functions in a pilot study with healthy controls: Insights from eye-tracking and fMRI.PloS one · 2024Article
- Impaired episodic verbal memory recall after 1 week and elevated forgetting in children after mild traumatic brain injury - results from a short-term longitudinal study.Frontiers in psychology · 2024Article
- Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging.International journal of environmental research and public health · 2023Review
- Multimodal MRI examination of structural and functional brain changes in older women with breast cancer in the first year of antiestrogen hormonal therapy.Breast cancer research and treatment · 2022Observational
- Functional near-infrared spectroscopy as a potential objective evaluation technique in neurocognitive disorders after traumatic brain injury.Frontiers in psychiatry · 2022Article
- Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis.Human brain mapping · 2021Review
- Abnormal Functional Network Topology and Its Dynamics during Sustained Attention Processing Significantly Implicate Post-TBI Attention Deficits in Children.Brain sciences · 2021Article
- Recurrent neural network-based acute concussion classifier using raw resting state EEG data.Scientific reports · 2021Article
- Neuroimaging in Pediatric Patients with Mild Traumatic Brain Injury: Relating the Current 2018 Centers for Disease Control Guideline and the Potential of Advanced Neuroimaging Modalities for Research and Clinical Biomarker Development.Journal of neurotrauma · 2021Review
- Co-localized impaired regional cerebrovascular reactivity in chronic concussion is associated with BOLD activation differences during a working memory task.Brain imaging and behavior · 2020Article
- Multiparametric MRI changes persist beyond recovery in concussed adolescent hockey players.Neurology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe neural substrate of post-concussive symptoms following the initial injury period after mild traumatic brain injury (mTBI) in pediatric populations remains poorly elucidated. This study examined neuropsychological, behavioral, and brain functioning in adolescents post-mTBI to assess whether persistent differences were detectable up to a year post-injury.
methodsNineteen adolescents on average 7.5 months post-mTBI completed neuropsychological testing and an fMRI auditory-verbal N-back working memory task. Parents completed behavioral ratings. The comparison group included 19 healthy controls matched to the mTBI group for demographic variables and N-back task performance.
resultsThere were no between-group differences for cognition or behavior ratings. The expected decreased accuracy and increased reaction time as N-back task difficulty increased were apparent. The mTBI group showed significantly greater brain activation than controls during the most difficult working memory load condition.
conclusionGreater working memory task-related activation was found in adolescents up to one year post-mTBI relative to controls, potentially indicating compensatory activation to support normal task performance. Differences in brain activation in the mTBI group so long after injury may indicate residual alterations in brain function much later than would be expected based on the typical pattern of symptom recovery, which could have important clinical implications.
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