Observational studyMedicine2015
Gender and Age Impacts on the Association Between Thyroid Function and Metabolic Syndrome in Chinese.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis.PloS one · 2019Pooled it
- DNA damage in thyroid cancer patients treated with radioactive iodine in Johannesburg, South Africa.EJNMMI reports · 2026Article
- Comorbidity Associations with Ocular Pain after Cataract Surgery: Overall and Sex-Stratified Analysis.AJO international · 2026Article
- Stability-aware LSTM-MPC framework for personalized levothyroxine dosing in Hashimoto's thyroiditis.Frontiers in endocrinology · 2026Article
- The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females.Frontiers in physiology · 2026Article
- Non-linear associations of the triglyceride-glucose index with thyroid function in a large Chinese population: a cross-sectional study.Frontiers in nutrition · 2026Article
- Thyroid Function Test Abnormalities in Human Immunodeficiency Virus Positive Patients on Antiretroviral Therapy at Matyazo Health Center, Huye, Rwanda.Rwanda journal of medicine and health sciences · 2025Article
- Thyroid Disorders and Their Impact on Metabolic Syndrome and Cardiovascular Risk: A Narrative Review.Cureus · 2025Review
- Thyroid Dysfunction Prevalence and Risk Factors in the Southeastern Part of Bangladesh: A Cross-Sectional Study.Health science reports · 2025Article
- Establishment of Reference Intervals for Serum Thyroid-related Hormones in the Chinese Oldest-old.International journal of medical sciences · 2025Article
- Thyroid-sparing volume-modulated arc therapy in patients with non-distant metastatic nasopharyngeal carcinoma: a feasibility study.Frontiers in oncology · 2025Article
- When gender matters: inequalities in health services utilization and risk factors monitoring after acute myocardial infarction.Frontiers in global women's health · 2025Article
- Article
- Health knowledge needs of administrative staff and related influencing factors: a cross-sectional data from Yuxi, China.Scientific reports · 2024Article
- Analyzing Comorbidity Patterns in Patients With Thyroid Disease Using Large-Scale Electronic Medical Records: Network-Based Retrospective Observational Study.Interactive journal of medical research · 2024Article
- Article
- Comprehensive Analysis of Drug Utilization Patterns, Gender Disparities, Lifestyle Influences, and Genetic Factors: Insights from Elderly Cohort Using g-NomicPharmaceuticals (Basel, Switzerland) · 2024Article
- Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population.International journal of molecular sciences · 2024Article
- Sex and Sleep Disruption as Contributing Factors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Autoimmune thyroid status in subclinical thyroid disorders in patients attending a tertiary care center in Nepal: a hospital-based cross-sectional study.BMC endocrine disorders · 2023Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between thyroid dysfunction and metabolic syndrome (MS) is complex. We aimed to explore the impact of gender and age on their association in a large Chinese cohort. This cross-sectional study enrolled 13,855 participants (8532 male, 5323 female), who self-reported as healthy without any known previous diseases. Clinical data including anthropometric measurements, thyroid function, and serum metabolic parameters were collected. The associations between thyroid function and MS of both genders were analyzed separately after dividing thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and age into subgroups. MS risks were calculated by binary logistic regression models. Young males had significantly higher MS prevalence than females, yet after menopause, females had higher prevalence than males. Females had higher incidence of thyroid dysfunction than males. By using TSH quartiles as the categorical variables and the lowest quartile as reference, significantly increased MS risk was demonstrated in quartile 4 for males, yet quartiles 3 and 4 for females. By using FT3 quartiles as the categorical variables, significantly increased MS risk was demonstrated in quartile 2 to 4 for females only. By using age subgroups as the categorical variables, significantly increased MS risk was shown in both genders, with females (4.408-58.455) higher than males (2.588-4.943). Gender and age had substantial influence on thyroid function and MS. Females with high TSH and high FT3 had higher MS risks than males. Aging was a risk for MS, especially for females. Urgent need is necessary to initiate interventional programs.
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