SynthesisMedicine2015
Osteoarticular Infections Caused by Non-Aspergillus Filamentous Fungi in Adult and Pediatric Patients: A Systematic Review.
Synthesis in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Bone and joint infections caused by mucormycetes: A challenging osteoarticular mycosis of the twenty-first century.Medical mycology · 2017Pooled it
- From misdiagnosis to precision management: Thoracic vertebral infection caused byMedical mycology case reports · 2026Article
- Article
- Delay in the Diagnosis of Osteoarticular Mucormycosis in Diabetic Ketoacidosis: A Learning Opportunity.Cureus · 2025Article
- Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections.Clinical microbiology reviews · 2024Review
- Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Scedosporium infection disseminated "from toe to head" in allogeneic stem cell transplant recipient: a case report.BMC infectious diseases · 2023Article
- Acremonium (Sarocladium) periprosthetic joint infection: case report, literature review, and proposed antifungal regimen.BMC infectious diseases · 2022Article
- Osteoarticular Mycoses.Clinical microbiology reviews · 2022Review
- Review
- Clinical utility of antifungal susceptibility testing.JAC-antimicrobial resistance · 2022Review
- Activity of Amphotericin B Formulations and Voriconazole, Alone or in Combination, against Biofilms ofAntimicrobial agents and chemotherapy · 2021Article
- Fungal osteomyelitis and septic arthritis in an immune competent man: The first report of invasive osteoarticular infection due toMedical mycology case reports · 2021Article
- A Canker Barking at the Wrong Knee:Open forum infectious diseases · 2021Article
- First case report of Cryptococcus laurentii knee infection in a previously healthy patient.BMC infectious diseases · 2020Article
- An Unusual Etiology for Osteomyelitis in an Immunocompetent Host.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Acute osteomyelitis and septic arthritis in children : A referral hospital-based study in Iran.Wiener medizinische Wochenschrift (1946) · 2017Article
- Reduced Multidrug Susceptibility Profile Is a Common Feature of Opportunistic Fusarium Species: Fusarium Multi-Drug Resistant Pattern.Journal of fungi (Basel, Switzerland) · 2017Review
- Aspergillus arthritis: analysis of clinical manifestations, diagnosis, and treatment of 31 reported cases.Medical mycology · 2017Article
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 8 countries.
Funding
Abstract
Osteoarticular mycoses due to non-Aspergillus moulds are uncommon and challenging infections. A systematic literature review of non-Aspergillus osteoarticular mycoses was performed using PUBMED and EMBASE databases from 1970 to 2013. Among 145 patients were 111 adults (median age 48.5 [16-92 y]) and 34 pediatric patients (median age 7.5 [3-15 y]); 114 (79.7%) were male and 88 (61.9%) were immunocompromised. Osteomyelitis was due to direct inoculation in 54.5%. Trauma and puncture wounds were more frequent in children (73.5% vs 43.5%; P = 0.001). Prior surgery was more frequent in adults (27.7% vs 5.9%; P = 0.025). Vertebral (23.2%) and craniofacial osteomyelitis (13.1%) with neurological deficits predominated in adults. Lower limb osteomyelitis (47.7%) and knee arthritis (67.8%) were predominantly seen in children. Hyalohyphomycosis represented 64.8% of documented infections with Scedosporium apiospermum (33.1%) and Lomentospora prolificans (15.8%) as the most common causes. Combined antifungal therapy and surgery was used in 69% of cases with overall response in 85.8%. Median duration of therapy was 115 days (range 5-730). When voriconazole was used as single agent for treatment of hyalohyphomycosis and phaeohyphomycosis, an overall response rate was achieved in 94.1% of cases. Non-Aspergillus osteoarticular mycoses occur most frequently in children after injury and in adults after surgery. Accurate early diagnosis and long-course therapy (median 6 mo) with a combined medical-surgical approach may result in favorable outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.