ArticleNeurology2016
Silent new ischemic lesions after index stroke and the risk of future clinical recurrent stroke.
Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03433235 (Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: a Randomized, Multi-center, Parallel-group Trial (PILOT)
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Automated detection of new cerebral infarctions and prognostic implications using deep learning on serial MRI.NPJ digital medicine · 2026Article
- Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study.European stroke journal · 2026Article
- A deep learning system for detecting silent brain infarction and predicting stroke risk.Nature biomedical engineering · 2025Article
- Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study.European stroke journal · 2025Article
- Establishment and Validation of the Nomogram Model and the Probability of Silent Cerebral Infarction After Ablation Atrial Fibrillation.Cardiovascular drugs and therapy · 2025Observational
- Association of Plaque Characteristics With New Ischemic Lesions After Carotid Artery Stenting.CNS neuroscience & therapeutics · 2025Article
- Risk factors and clinical significance of post-stroke incident ischemic lesions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Detection of microemboli in patients with acute ischaemic stroke and atrial fibrillation suggests poor functional outcome.European stroke journal · 2024Article
- Global outflow angle influences silent ischemic events in coil embolization for unruptured distal anterior cerebral artery aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- The risk factors of old silent brain infarctions in carotid artery stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Multiphase arterial spin labeling imaging to predict early recurrent ischemic lesion in acute ischemic stroke.Scientific reports · 2022Article
- Predictive value of perfusion weighted imaging for early new lesions after stroke patients receive endovascular treatment.Quantitative imaging in medicine and surgery · 2021Article
- High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke.Scientific reports · 2021Article
- Corneal confocal microscopy identifies greater corneal nerve damage in patients with a recurrent compared to first ischemic stroke.PloS one · 2020Article
- Article
- Early New Ischemic Lesions Located Outside the Initially Affected Vascular Territory Appear More Often in Stroke Patients with Elevated Glycated Hemoglobin (HbA1c).Frontiers in neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test whether a silent new ischemic lesion (SNIL) on MRI after stroke predicted future recurrent ischemic stroke or vascular events.
methodsIn this prospective study, we analyzed data from patients presenting with acute ischemic stroke who underwent MRI <24 hours and 5 and 30 days after symptom onset. The presence of a SNIL at 5 (5D-SNIL) and 30 (30D-SNIL) days was determined on diffusion-weighted and fluid-attenuated inversion recovery images. Patients were contacted every 3-6 months to identify recurrent clinical events. The log-rank test and Cox proportional hazard model were used to estimate the hazard ratio of recurrent ischemic stroke and composites of recurrent ischemic stroke, transient ischemic attack, acute coronary syndrome, and vascular death.
resultsThe 5D- and 30D-SNILs were found in 24.4% (66/270) and 7.4% (19/256) of patients. During the 5-year follow-up, clinical events were observed in 42 patients (15.6%). The 5D- and 30D-SNIL independently predicted recurrent ischemic stroke (hazard ratio [95% confidence interval] 2.9 [1.3-6.4] and 9.6 [4.1-22.1], respectively) and composite vascular events (2.4 [1.3-4.5] and 6.1 [3.1-12.4], respectively).
conclusionsPatients with a SNIL within the first few weeks after index stroke have an increased risk of recurrent ischemic stroke or vascular events. The presence of a SNIL on MRI could serve as a surrogate endpoint for clinical recurrence in secondary prevention clinical trials.
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Registered trials
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