Evidence map›Paper›PMID 26683589›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2016

Children of chronically ill parents: Relationship between parental multiple sclerosis and childhood developmental health.

Neda Razaz, K S Joseph, W Thomas Boyce, Martin Guhn, Barry Forer, Robert Carruthers, Ruth Ann Marrie, Helen Tremlett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
10.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Neda RazazSchool of Population and Public Health and Department of Obstetrics & Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
K S JosephSchool of Population and Public Health and Department of Obstetrics & Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
W Thomas BoyceDivision of Developmental-Behavioral Pediatrics, Department of Pediatrics, University of California, San Francisco, CA, USA.
Martin GuhnSchool of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Barry ForerSchool of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Robert CarruthersCentre for Brain Health, Division of Neurology, Faculty of Medicine, University of British Columbia/Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Ruth Ann MarrieDepartments of Internal Medicine and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Helen TremlettCentre for Brain Health, Division of Neurology, Faculty of Medicine, University of British Columbia/Vancouver Coastal Health Research Institute, Vancouver, BC, Canada helen.tremlett@ubc.ca.
University of British Columbia · CAUniversity of California, San Francisco · USUniversity of Manitoba · CAVancouver Coastal Health · CAVancouver Coastal Health Research Institute · CA

Funding

CIHR MOP-119393
6 · The paper itself

Abstract

backgroundExposure to parental chronic illness is associated with adverse developmental outcomes.

objectiveWe examined the association between parental multiple sclerosis (MS) and parental MS-related clinical factors on developmental health.

methodsWe conducted a population-based cohort study in British Columbia, Canada, using linked health databases. The outcome was childhood development at 5 years of age, expressed as vulnerability on the Early Development Instrument (EDI). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.

resultsMS-affected parents (n = 783) were older, more likely to be English speakers, and had higher rates of mental health morbidity (39.6% vs 22.2%, p < 0.001) than unaffected parents (n = 2988). In the adjusted models, children of mothers with MS (aOR = 0.62, 95% CI = 0.44-0.87), but not children of the fathers with MS, had a lower risk of vulnerability on the social development domain of the EDI. However, mental health comorbidity (aOR = 1.62, 95% CI = 1.05-2.50) and physical comorbidity (aOR = 1.67, 95% CI = 1.05-2.64) among mothers with MS were associated with increased vulnerability on the EDI.

conclusionMaternal MS, but not paternal MS, was associated with lower rates of developmental vulnerability on the social development domain. However, mental and physical comorbidity among MS-affected mothers were associated with increased developmental vulnerability in children.

Indexed as

Child DevelopmentChild of Impaired ParentsMultiple SclerosisSocial ChangeAdultAnxiety DisordersBritish ColumbiaCase-Control StudiesChildChild, PreschoolComorbidityDepressive DisorderFathersFemaleHumansLogistic Modelsanxietychild developmentcohort studiesdepressionMultiple sclerosis

Identifiers

PMID26683589
PMCPMC5051600
OpenAlexW2215855864

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.