Evidence map›Paper›PMID 26683358›Full record

SynthesisOncotarget2016

Diabetes mellitus and the risk of glioma: a meta-analysis.

Luqian Zhao, Zhiping Zheng, Ping Huang

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Review
  9. Article
  10. Pericytes Are Immunoregulatory Cells in Glioma Genesis and Progression.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Luqian ZhaoDepartment of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
Zhiping ZhengDepartment of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
Ping HuangDepartment of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangzhou, China.
Guangzhou Medical University · CNGuangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some studies reported a statistically significant inverse association between diabetes mellitus (DM) and risk of gliomas. However, the result is still controversial. We thus did a meta-analysis and summarized the evidence on the incidence of gliomas that has been studied in its association with DM. Seven case-control studies and 4 cohort studies were selected in this meta-analysis (n = 5898251). DM was significantly associated with decreased risk of gliomas (OR = 0.79; 95% CI 0.67 - 0.93; P = 0.004; I2 = 59%). In the subgroup analysis of race, Caucasians of DM showed decreased risk of gliomas (OR = 0.81; 95% CI 0.69 - 0.94; P = 0.007). In the subgroup analysis of design, a statistically significant protective effect of DM on gliomas was observed in case-control studies (OR = 0.68; 95 % CI, 0.53-0.87; P = 0.002), while no such effect was observed in cohort studies (OR = 0.97; 95 % CI, 0.83-1.13; P = 0.70). In a further stratified analysis by gender, a significant association was found among males with DM (OR = 0.83; 95 % CI, 0.70-0.99; P = 0.04). No significant association was found between females with DM and gliomas (OR = 0.97; 95 % CI, 0.78-1.21; P = 0.81). In summary, this meta-analysis of current evidence suggests that DM is significantly associated with decreased gliomas risk in Caucasian and males.

Indexed as

Brain NeoplasmsCase-Control StudiesDiabetes Mellitus, Type 2FemaleGliomaHumansMalePrognosisRisk Factorsassociationdiabetesgliomameta-analysis

Identifiers

PMID26683358
PMCPMC4826220
OpenAlexW2236670887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.