Evidence map›Paper›PMID 26683219›Full record

ArticleJournal of the American Heart Association2015

Proteinuria Is an Independent Risk Factor for First Incident Stroke in Adults Under Treatment for Hypertension in China.

Chunyan Zhang, Xiaobin Wang, Mingli He, Xianhui Qin, Genfu Tang, Xin Xu, Yu Wang, Yong Huo, Yefeng Cai, Jia Fu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Proteinuria and risk of stroke in patients with hypertension: The Kailuan cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2018
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Chunyan ZhangNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Xiaobin WangDepartment of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (X.W.).
Mingli HeDepartment of Neurology, First People's Hospital, Lianyungang, China (M.H.).
Xianhui QinNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Genfu TangInstitute for Biomedicine, Anhui Medical University, Hefei, China (G.T.).
Xin XuNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Yu WangNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Yong HuoCardiology Department, Peking University First Hospital, Beijing, China (Y.H.).
Yefeng CaiDepartment of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China (Y.C.).
Jia FuDepartment of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, China (J.F.).
Gang ZhaoDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China (G.Z.).
Qiang DongDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China (Q.D.).
Xiping XuNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.) AUSA Research Institute, Shenzhen AUSA Pharmed Co Ltd, Shenzhen, China (X.X.).
Binyan WangNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Fan Fan HouNational Clinical Research Study Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.Q., X.X., Y.W., X.X., B.W., F.F.H.).
Southern Medical University · CNAnhui Medical University · CNNanfang Hospital · CNAir Force Medical University · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNHuashan Hospital · CNJohns Hopkins University · USPeking University First Hospital · CNThe First People’s Hospital of Lianyungang · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConflicting evidence exists regarding whether reduced estimated glomerular filtration rate (eGFR) and proteinuria are independent risk factors for stroke and its subtypes in hypertensive patients. This study investigated the association of these renal measures with first incident stroke in adults under treatment for hypertension in China. METHODS AND

resultsThe study included 19 599 adults aged 45 to 75 years who participated in the China Stroke Primary Prevention Trial. Baseline eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine equation. Proteinuria was assessed by qualitative dipstick urinalysis and in a subset by the quantitative albumin-creatinine ratio method. Cox regression analysis was used to examine the effects of eGFR and proteinuria on the risk of first incident stroke. During a median of 4.5 years of follow-up, a total of 585 first strokes (472 ischemic strokes) were identified. Compared to participants without proteinuria, participants with proteinuria (trace or more by dipstick) had a 35% increased risk of first stroke: the adjusted hazard ratio (HR) (95% CI) was 1.35 (1.09-1.66, P=0.005). The results were robust in subgroup analyses. In a subset with data on proteinuria measured by quantitative albumin-creatinine ratio, a similar association was found. In both independent and combined analyses with proteinuria, eGFR was not significantly associated with stroke.

conclusionsIn adults under treatment for hypertension in China, baseline proteinuria measured by dipstick or quantitative albumin-creatinine ratio, but not reduced eGFR, was found to be an independent risk factor for first incident stroke and ischemic stroke.

Indexed as

AgedAntihypertensive AgentsChinaFemaleGlomerular Filtration RateHumansHypertensionMaleMiddle AgedProteinuriaRisk FactorsStrokeAntihypertensive Agentsalbumin–creatinine ratioChinese hypertensive adultsestimated glomerular filtration ratefirst incident strokeproteinuria

Identifiers

PMID26683219
PMCPMC4845256
OpenAlexW2200786384

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.