ArticleRheumatology (Oxford, England)2016
Impact of gout on the risk of atrial fibrillation.
Article in Rheumatology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis.Reviews in cardiovascular medicine · 2022Pooled it
- Pooled it
- Predictive factors for atrial fibrillation recurrence after radiofrequency ablation: a multifactorial approach.BMC cardiovascular disorders · 2026Article
- Increased risk of atrial fibrillation in young adults with gout: a nationwide cohort study.Frontiers in cardiovascular medicine · 2026Article
- Risk of Sudden Sensorineural Hearing Loss in Patients with Gout: A Population-Level Study in a South Korean National Health Screening Cohort.Journal of clinical medicine · 2025Article
- Assessing the relationship between gout and the risk of cataract in community-dwelling older adults: mediation and moderation analysis.Frontiers in medicine · 2025Article
- Gout: global epidemiology, risk factors, comorbidities and complications: a narrative review.BMC musculoskeletal disorders · 2024Review
- Comparison Between Early-Onset and Common Gout: A Systematic Literature Review.Rheumatology and therapy · 2023Review
- Atrial Fibrillation Risk and Urate-Lowering Therapy in Patients with Gout: A Cohort Study Using a Clinical Database.Biomedicines · 2022Article
- The Risk of BPPV, Meniere's Disease, and Vestibular Neuronitis in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort.Journal of clinical medicine · 2022Article
- Community Practice Experiences with a Variety of Immunomodulatory Agents Co-Administered with Pegloticase for the Treatment of Uncontrolled Gout.Rheumatology and therapy · 2022Article
- Association between Stroke Risk and Influenza Vaccination in Patients with Gout: A Nationwide Population-Based Study.Vaccines · 2022Article
- Stroke Risk in Patients with Gout: A Nationwide Retrospective Cohort Study in Taiwan.Journal of clinical medicine · 2022Article
- Combined Effect of Homocysteine and Uric Acid to Identify Patients With High Risk for Subclinical Atrial Fibrillation.Journal of the American Heart Association · 2022Article
- The Relationship between Uric Acid and the Development, Complication, and Prognosis of Atrial Fibrillation: The Views from a Clinical Study.International journal of endocrinology · 2022Review
- Influenza vaccination and risk of atrial fibrillation in patients with gout: A nationwide population-based cohort study.Frontiers in pharmacology · 2022Article
- What Has Dual Energy CT Taught Us About Gout?Current rheumatology reports · 2021Review
- Burden of atrial fibrillation in patients with rheumatic diseases.World journal of clinical cases · 2021Article
- The risk and severity of stroke in patients with atrial fibrillation and gout: A National Representative Database study.Journal of arrhythmia · 2021Article
- Urate Crystals; Beyond Joints.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.
methodsFrom the UK Clinical Practice Research Data-link, 45 378 incident gout patients and 45 378 age-, sex-, practice-, registration year- and index year-matched controls were identified. Index dates were initial diagnosis date for gout patients and their matched controls. The risk of AF at diagnosis [odds ratios (ORs), using conditional logistic regression] and after the diagnosis of gout [hazard ratios (HRs), using Cox proportional models] were estimated, adjusted for BMI, smoking, alcohol consumption, ischaemic heart disease, heart failure, heart valve disease, hyperthyroidism and other comorbidities and medications.
resultsThe prevalence of AF at index date in gout patients (male, 72.3%; mean age, 62.4 ± 15.1 years) was 7.42% (95% CI 7.18, 7.66%) and in matched controls 2.83% (95% CI 2.67, 2.98%). The adjusted OR (95% CI) was 1.45 (1.29, 1.62). The cumulative probability of AF at 1, 2, 5 and 10 years after index date was 1.08, 2.03, 4.77 and 9.68% in gout patients and 0.43, 1.08, 2.95 and 6.33% in controls, respectively (log-rank test, P < 0.001). The adjusted HR (95% CIs) was 1.09 (1.03, 1.16).
conclusionThis population-based study indicates that gout is independently associated with a higher risk of AF at diagnosis and the risk is also higher after the diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.