Evidence map›Paper›PMID 26683139›Full record

ArticleNeuro-oncology2016

Predicting outcome of epilepsy after meningioma resection.

Hans-Georg Wirsching, Corinne Morel, Corinne Gmür, Marian Christoph Neidert, Christian Richard Baumann, Antonios Valavanis, Elisabeth Jane Rushing, Niklaus Krayenbühl, Michael Weller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  4. Management of epilepsy in brain tumors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Guideline
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  6. Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hans-Georg WirschingDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Corinne MorelDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Corinne GmürDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Marian Christoph NeidertDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Christian Richard BaumannDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Antonios ValavanisDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Elisabeth Jane RushingDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Niklaus KrayenbühlDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
Michael WellerDepartment of Neurology, University Hospital Zurich, Switzerland (H.-G.W., C.M., C.G., C.R.B., M.W.); Department of Neurosurgery, University Hospital Zurich, Switzerland (M.C.N., N.K.); Department of Neuroradiology, University Hospital Zurich, Switzerland (A.V.); Department of Neuropathology, University Hospital Zurich, Switzerland (E.J.R.).
University Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical excision is the standard treatment for intracranial meningiomas. Epilepsy is a major cause of morbidity in meningioma patients, but postoperative control of epilepsy is not achieved in a substantial fraction of patients. The purpose of this study was to define risk factors for postoperative epilepsy.

methodsPatients treated for histologically confirmed intracranial meningioma at the University Hospital Zurich between 2000 and 2013 were retrospectively analyzed. Demographic, clinical, imaging, and electroencephalographic data were assessed. A binary regression model was applied to identify risk factors for postoperative epilepsy.

resultsOf the 779 patients analyzed, epileptic seizures occurred in 244 (31.3%) patients before surgery and in 204 (26.6%) patients after surgery. Of the 244 patients with preoperative epilepsy, 144 (59.0%) became seizure-free after surgery; of the 535 patients without preoperative seizures, 104 (19.4%) suffered from epilepsy after surgery. Risk factors for postoperative epilepsy were preoperative epilepsy (odds ratio [OR]: 3.46 [95% confidence interval {CI}: 2.32-5.16]), major surgical complications including CNS infections (OR: 5.89 [95% CI: 1.53-22.61]), hydrocephalus (OR: 3.27 [95% CI: 1.35-7.95]), recraniotomy (OR: 2.91 [95% CI: 1.25-6.78]), and symptomatic intracranial hemorrhage (OR: 2.60 [95% CI: 1.17-5.76]) as well as epileptiform EEG potentials (OR: 2.52 [95% CI: 1.36-4.67]), younger age (OR: 1.74 [(95% CI: 1.18-2.58]), and tumor progression (OR: 1.92 [95% CI: 1.16-3.18]). Postoperative improvement or recovery from preoperative neurologic deficits was associated with improved seizure control (OR: 0.46 [95% CI: 0.25-0.85], P = .013).

conclusionWe suggest prospective validation of a score ("STAMPE2") based on clinical findings, EEG, and brain-imaging measures to estimate postoperative seizure risk and guide anticonvulsant treatment in meningioma patients.

Indexed as

AdolescentAdultAgedAged, 80 and overAnticonvulsantsElectroencephalographyEpilepsyFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedPostoperative PeriodRetrospective StudiesSeizuresAnticonvulsantsEEGmeningiomapostoperative epilepsySTAMPE2

Identifiers

PMID26683139
PMCPMC4896539
OpenAlexW2290522936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.