ArticleJournal of veterinary internal medicine
Naturally Occurring Adrenocortical Insufficiency--An Epidemiological Study Based on a Swedish-Insured Dog Population of 525,028 Dogs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Addisonian Crisis Mimicking Acute Kidney Injury in Dogs: A Retrospective Study of 34 Dogs Diagnosed with Acute Kidney Injury in Romania.Life (Basel, Switzerland) · 2026Article
- Clinical characteristics, treatment, and outcomes of hypoadrenocorticism in dogs.The Journal of small animal practice · 2025Article
- Efficacy and side effects of long-term treatment strategies of canine primary hypoadrenocorticism.Frontiers in veterinary science · 2025Article
- The impact of age on the Na:K ratio: observations from a general canine population.Frontiers in veterinary science · 2025Article
- Comparison between typical primary and eunatraemic, eukalaemic hypoadrenocorticism: 92 cases.Irish veterinary journal · 2024Article
- Can we predict hypoadrenocorticism in dogs with resting hypocortisolemia? A predictive model based on clinical, haematological, and biochemical variables.Frontiers in veterinary science · 2024Article
- A qualitative analysis of the impact of canine hypoadrenocorticism on the quality of life of owners.BMC veterinary research · 2023Article
- Banking on a new understanding: translational opportunities from veterinary biobanks.GeroScience · 2023Review
- Characterization of clinicopathologic and abdominal ultrasound findings in dogs with glucocorticoid deficient hypoadrenocorticism.Journal of veterinary internal medicine · 2022Article
- Evaluation of a machine learning tool to screen for hypoadrenocorticism in dogs presenting to a teaching hospital.Journal of veterinary internal medicine · 2022Article
- Diagnosis of canine spontaneous hypoadrenocorticism.Canine medicine and genetics · 2022Review
- Evaluation of resting cortisol concentration testing in dogs with chronic gastrointestinal signs.Journal of veterinary internal medicine · 2022Article
- Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey.Veterinary sciences · 2021Article
- The epidemiology of cruciate ligament rupture in an insured Swedish dog population.Scientific reports · 2021Article
- Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors.The Journal of small animal practice · 2021Article
- Genetic characterization of Addison's disease in Bearded Collies.BMC genomics · 2020Article
- Randomised clinical non-inferiority trial comparing two formulations of desoxycortone pivalate for the treatment of canine primary hypoadrenocorticism.The Veterinary record · 2020Article
- Prevalence and characterization of hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease: A multicenter study.Journal of veterinary internal medicine · 2020Article
- A case of canine hypoadrenocorticism needing blood transfusion for severe acute anemia due to gastrointestinal hemorrhage.The Journal of veterinary medical science · 2020Article
- DLA class II haplotypes show sex-specific associations with primary hypoadrenocorticism in Standard Poodle dogs.Immunogenetics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNaturally occurring adrenocortical insufficiency (NOAI) in dogs is considered an uncommon disease with good prognosis with hormonal replacement treatment. However, there are no epidemiological studies with estimates for the general dog population.
objectivesTo investigate the epidemiological characteristics of NOAI in a large population of insured dogs. ANIMALS: Data were derived from 525,028 client-owned dogs insured by a Swedish insurance company representing 2,364,652 dog-years at risk (DYAR) during the period between 1995-2006.
methodsRetrospective cohort study. Incidence rates, prevalences, and relative risks for dogs with NOAI (AI with no previous claim for hypercortisolism), were calculated for the whole dog population, and for subgroups divided by breed and sex. Mortality rates were calculated and compared in dogs with NOAI and the remaining dogs overall.
resultsIn total 534 dogs were identified with NOAI. The overall incidence was 2.3 cases per 10,000 DYAR. The relative risk of disease was significantly higher in the Portuguese Water Dog, Standard Poodle, Bearded Collie, Cairn Terrier, and Cocker Spaniel compared with other breeds combined. Female dogs overall were at higher risk of developing AI than male dogs (RR 1.85; 95% CI, 1.55-2.22; P < .001). The relative risk of death was 1.9 times higher in dogs with NOAI than in dogs overall. CONCLUSION AND CLINICAL IMPORTANCE: The data supports the existence of breed-specific differences in incidence rates of NOAI in dogs.
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