ArticleJournal of neurophysiology2016
Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04749771 (A Scaleable Video Coaching Intervention for Opioid-using Mothers), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Scaleable Video Coaching Intervention for Opioid-using Mothers
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
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- Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction.International journal of molecular sciences · 2021Review
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Pubertal testosterone correlates with adolescent impatience and dorsal striatal activity.Developmental cognitive neuroscience · 2020Article
- Neural Basis of Increased Cognitive Control of Impulsivity During the Mid-Luteal Phase Relative to the Late Follicular Phase of the Menstrual Cycle.Frontiers in human neuroscience · 2020Article
- Presynaptic dopamine function measured with [Scientific reports · 2019Article
- Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery.Brain sciences · 2019Article
- Cognitive and behavioral training interventions to promote self-control.Journal of experimental psychology. Animal learning and cognition · 2019Review
- Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Impulsiveness and Cognitive Patterns. Understanding the Perfectionistic Responses in Spanish Competitive Junior Athletes.Frontiers in psychology · 2019Article
- Integrating Preclinical and Clinical Models of Negative Urgency.Frontiers in psychiatry · 2019Review
- Altered structural and functional brain network overall organization predict human intertemporal decision-making.Human brain mapping · 2019Article
- The relationships among aberrant salience, reward motivation, and reward sensitivity.International journal of methods in psychiatric research · 2018Article
- Dopamine Synthesis Capacity is Associated with D2/3 Receptor Binding but Not Dopamine Release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Decline of prefrontal cortical-mediated executive functions but attenuated delay discounting in aged Fischer 344 × brown Norway hybrid rats.Neurobiology of aging · 2017Article
- Neural Systems Underlying Individual Differences in Intertemporal Decision-making.Journal of cognitive neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Converging evidence links individual differences in mesolimbic and mesocortical dopamine (DA) to variation in the tendency to choose immediate rewards ("Now") over larger, delayed rewards ("Later"), or "Now bias." However, to date, no study of healthy young adults has evaluated the relationship between Now bias and DA with positron emission tomography (PET). Sixteen healthy adults (ages 24-34 yr; 50% women) completed a delay-discounting task that quantified aspects of intertemporal reward choice, including Now bias and reward magnitude sensitivity. Participants also underwent PET scanning with 6-[(18)F]fluoro-l-m-tyrosine (FMT), a radiotracer that measures DA synthesis capacity. Lower putamen FMT signal predicted elevated Now bias, a more rapidly declining discount rate with increasing delay time, and reduced willingness to accept low-interest-rate delayed rewards. In contrast, lower FMT signal in the midbrain predicted greater sensitivity to increasing magnitude of the Later reward. These data demonstrate that intertemporal reward choice in healthy humans varies with region-specific measures of DA processing, with regionally distinct associations with sensitivity to delay and to reward magnitude.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.