ArticleThe Journal of cell biology1989
Expression of nuclear lamin A and muscle-specific proteins in differentiating muscle cells in ovo and in vitro.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Altered Lamin A/C splice variant expression as a possible diagnostic marker in breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Nuclear lamins.Cold Spring Harbor perspectives in biology · 2010Review
- Forced expression and assembly of rat cardiac troponin T isoforms in cultured muscle and nonmuscle cells.Journal of muscle research and cell motility · 1993Article
- Membrane-associated lamins in Xenopus egg extracts: identification of two vesicle populations.The Journal of cell biology · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Primary cultures and tissue samples of chicken embryonic muscle were immunologically probed for the expression of muscle-specific proteins, such as myosin heavy chain and the tropomyosins, as well as for the nuclear lamina protein, lamin A. As determined by quantitative immunoblotting, the expression of lamin A and the muscle-specific proteins were at low levels or absent in predifferentiation myoblasts both in vitro and in ovo. During differentiation, an increase of lamin A expression preceded the induction to high levels of expression of muscle-specific proteins. Immunofluorescence staining of chicken embryonic muscle cells in culture also indicates an accumulation of lamin A before the induction of muscle-specific proteins expression. Furthermore, the accumulation of lamin A reached a plateau before the muscle-specific proteins during muscle development. In two dimensional NEPHGE gel analysis of immunoprecipitated lamin A, no detectable change in the ratio of the acidic/basic isoelectric variants of lamin A was observed during myogenesis. A potential role for lamin A in the mechanisms which underlie the differential and coordinate expression of muscle-specific genes is proposed.
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