ArticleShock (Augusta, Ga.)2016
Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury.
Article in Shock (Augusta, Ga.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model.Scientific reports · 2025Article
- Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury.ImmunoHorizons · 2022Article
- Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut.Advances in geriatric medicine and research · 2022Article
- The role and therapeutic potential of gut microbiome in severe burn.Frontiers in cellular and infection microbiology · 2022Review
- Re-examining chemically defined liquid diets through the lens of the microbiome.Nature reviews. Gastroenterology & hepatology · 2021Review
- Potential Associations Between Microbiome and COVID-19.Frontiers in medicine · 2021Review
- Crosstalk between gut microbiota and sepsis.Burns & trauma · 2021Review
- Potential Mechanisms Linking Food-Derived MicroRNAs, Gut Microbiota and Intestinal Barrier Functions in the Context of Nutrition and Human Health.Frontiers in nutrition · 2021Review
- Targeting the gut to prevent sepsis from a cutaneous burn.JCI insight · 2020Article
- The Microbiome as a Therapeutic Target for Multiple Sclerosis: Can Genetically Engineered Probiotics Treat the Disease?Diseases (Basel, Switzerland) · 2020Review
- Identification of Metagenomics Structure and Function Associated With Temporal Changes in Rat (Rattus norvegicus) Skin Microbiome During Health and Cutaneous Burn.Journal of burn care & research : official publication of the American Burn Association · 2020Article
- A Gut Feeling: The Importance of the Intestinal Microbiota in Psychiatric Disorders.Frontiers in immunology · 2020Review
- Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.Shock (Augusta, Ga.) · 2020Article
- Temporal shifts in the mycobiome structure and network architecture associated with a rat (Rattus norvegicus) deep partial-thickness cutaneous burn.Medical mycology · 2020Article
- Review
- Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology.Cell reports · 2019Article
- Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice.Burns & trauma · 2019Article
- The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant Organisms.The American journal of the medical sciences · 2018Article
- Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The gut microbiome is a community of commensal organisms that are known to play a role in nutrient production as well as gut homeostasis. The composition of the gut flora can be affected by many factors; however, the impact of burn injury on the microbiome is not fully known. Here, we hypothesized that burn-induced changes to the microbiome would impact overall colon health. After scald-burn injury, cecal samples were analyzed for aerobic and anaerobic colony forming units, bacterial community, and butyrate levels. In addition, colon and total intestinal permeabilities were determined. These parameters were further determined in a germ-reduced murine model. Following both burn injury and germ reduction, we observed decreases in aerobic and anaerobic bacteria, increased colon permeability and no change to small intestinal permeability. After burn injury, we further observed a significant decrease in the butyrate producing bacteria R. Gnavus, C. Eutactus, and Roseburia species as well as decreases in colonic butyrate. Finally, in mice that underwent burn followed by fecal microbiota transplant, bacteria levels and mucosal integrity were restored. Altogether our data demonstrate that burn injury can alter the microbiome leading to decreased butyrate levels and increased colon permeability. Of interest, fecal microbiota transplant treatment was able to ameliorate the burn-induced changes in colon permeability. Thus, fecal transplantation may represent a novel therapy in restoring colon health after burn injury.
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