ArticleMayo Clinic proceedings2016
Post-September 11, 2001, Incidence of Systemic Autoimmune Diseases in World Trade Center-Exposed Firefighters and Emergency Medical Service Workers.
Article in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown.Frontiers in immunology · 2019Trial
- Prolonged brain cytokine elevation and microgliosis following exposure to World Trade Center dust particulate matter in male spontaneously hypertensive rats.Journal of immunotoxicology · 2026Article
- Occupational Exposure to Silica Dust and Silicosis Risk in Chinese Noncoal Mines: Qualitative and Quantitative Risk Assessment.JMIR public health and surveillance · 2024Article
- Association between Adverse Childhood Experiences and Multiple Sclerosis in Icelandic Women-A Population-Based Cohort Study.Brain sciences · 2022Article
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- Current global perspectives on silicosis-Convergence of old and newly emergent hazards.Respirology (Carlton, Vic.) · 2022Review
- The role of environmental exposures and gene-environment interactions in the etiology of systemic lupus erythematous.Journal of internal medicine · 2022Review
- The Relationship between 9/11 Exposure, Systemic Autoimmune Disease, and Post-Traumatic Stress Disorder: A Mediational Analysis.International journal of environmental research and public health · 2022Article
- Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.American journal of industrial medicine · 2022Article
- Health effects following exposure to dust from the World Trade Center disaster: An update.Life sciences · 2022Review
- The World Trade Center Health Program: Twenty years of health effects research.American journal of industrial medicine · 2021Article
- World Trade Center Health Program: First Decade of Research.International journal of environmental research and public health · 2020Review
- Sex and Gender in Research on Healthcare Workers in Conflict Settings: A Scoping Review.International journal of environmental research and public health · 2020Article
- Evaluation of Medical Surveillance and Incidence of Post-September 11, 2001, Thyroid Cancer in World Trade Center-Exposed Firefighters and Emergency Medical Service Workers.JAMA internal medicine · 2020Article
- Systemic Autoimmune Disease Among Adults Exposed to the September 11, 2001 Terrorist Attack.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Long-term Cardiovascular Disease Risk Among Firefighters After the World Trade Center Disaster.JAMA network open · 2019Article
- Cell type-specific gene expression patterns associated with posttraumatic stress disorder in World Trade Center responders.Translational psychiatry · 2019Article
- Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster.International journal of environmental research and public health · 2018Review
- Assessment of cumulative health risk in the World Trade Center general responder cohort.American journal of industrial medicine · 2018Article
- Understanding the role of environmental factors in the development of systemic lupus erythematosus.Best practice & research. Clinical rheumatology · 2017Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo estimate the incidence of selected systemic autoimmune diseases (SAIDs) in approximately 14,000 male rescue/recovery workers enrolled in the Fire Department of the City of New York (FDNY) World Trade Center (WTC) Health Program and to compare FDNY incidence to rates from demographically similar men in the Rochester Epidemiology Project (REP), a population-based database in Olmsted County, Minnesota. PATIENTS AND
methodsWe calculated incidence for specific SAIDs (rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and others) and combined SAIDs diagnosed from September 12, 2001, through September 11, 2014, and generated expected sex- and age-specific rates based on REP rates. Rates were stratified by level of WTC exposure (higher vs lower). Standardized incidence ratios (SIRs), which are the ratios of the observed number of cases in the FDNY group to the expected number of cases based on REP rates, and 95% CIs were calculated.
resultsWe identified 97 SAID cases. Overall, FDNY rates were not significantly different from expected rates (SIR, 0.97; 95% CI, 0.77-1.21). However, the lower WTC exposure group had 9.9 fewer cases than expected, whereas the higher WTC exposure group had 7.7 excess cases.
conclusionMost studies indicate that the healthy worker effect reduces the association between exposure and outcome by about 20%, which we observed in the lower WTC exposure group. Overall rates masked differences in incidence by level of WTC exposure, especially because the higher WTC exposure group was relatively small. Continued surveillance for early detection of SAIDs in high WTC exposure populations is required to identify and treat exposure-related adverse effects.
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