ArticleBiophysical journal2015
Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Mutations in Genes with a Role in Cell Envelope Biosynthesis Render Gram-Negative Bacteria Highly Susceptible to the Anti-Infective Small Molecule D66.Microorganisms · 2025Article
- Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics.Nature microbiology · 2025Article
- Plant-Derived Natural Products for the Treatment of Bacterial Infections.Handbook of experimental pharmacology · 2025Review
- Identification of amino acid residue in theJournal of virology · 2024Article
- Defense mechanisms ofFrontiers in antibiotics · 2024Review
- Phage-resistant mutations impact bacteria susceptibility to future phage infections and antibiotic response.Ecology and evolution · 2023Article
- A Single Nucleotide Polymorphism inFrontiers in microbiology · 2021Article
- Structural Changes in Films of Pulmonary Surfactant Induced by Surfactant Vesicles.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Studying the surfaces of bacteria using neutron scattering: finding new openings for antibiotics.Biochemical Society transactions · 2020Review
- Article
- Peptoid drug discovery and optimization via surface X-ray scattering.Biopolymers · 2019Review
- The cyclic peptide labaditin does not alter the outer membrane integrity of Salmonella enterica serovar Typhimurium.Scientific reports · 2019Article
- Both Intrinsically Disordered Regions and Structural Domains Evolve Rapidly in Immune-Related Mammalian Proteins.International journal of molecular sciences · 2018Article
- Expression of Granulisyn, Perforin and Granzymes in Human Milk over Lactation and in the Case of Maternal Infection.Nutrients · 2018Article
- Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes.Biochimica et biophysica acta. Biomembranes · 2018Article
- Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review.International journal of environmental research and public health · 2018Review
- Atomistic Scale Effects of Lipopolysaccharide Modifications on Bacterial Outer Membrane Defenses.Biophysical journal · 2018Article
- Cyclization Improves Membrane Permeation by Antimicrobial Peptoids.Langmuir : the ACS journal of surfaces and colloids · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Small hydrophilic antibiotics traverse the outer membrane of Gram-negative bacteria through porin channels. Large lipophilic agents traverse the outer membrane through its bilayer, containing a majority of lipopolysaccharides in its outer leaflet. Genes controlled by the two-component regulatory system PhoPQ modify lipopolysaccharides. We isolate lipopolysaccharides from isogenic mutants of Salmonella sp., one lacking the modification, the other fully modified. These lipopolysaccharides were reconstituted as monolayers at the air-water interface, and their properties, as well as their interaction with a large lipophilic drug, novobiocin, was studied. X-ray reflectivity showed that the drug penetrated the monolayer of the unmodified lipopolysaccharides reaching the hydrophobic region, but was prevented from this penetration into the modified lipopolysaccharides. Results correlate with behavior of bacterial cells, which become resistant to antibiotics after PhoPQ-regulated modifications. Grazing incidence x-ray diffraction showed that novobiocin produced a striking increase in crystalline coherence length, and the size of the near-crystalline domains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.