ArticleBiophysical journal2015
Seeds of Locally Aligned Motion and Stress Coordinate a Collective Cell Migration.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes.Biophysical journal · 2025Article
- Coupling during collective cell migration is controlled by a vinculin mechanochemical switch.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell culture media dependent in vitro dynamics and culture characteristics of adult caprine dermal fibroblast cells.Scientific reports · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- DynaMorph: self-supervised learning of morphodynamic states of live cells.Molecular biology of the cell · 2022Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Community standards for open cell migration data.GigaScience · 2020Article
- The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics.Biophysical journal · 2019Article
- Matrix feedback enables diverse higher-order patterning of the extracellular matrix.PLoS computational biology · 2019Article
- Characterization of Biological Motion Using Motion Sensing Superpixels.Bio-protocol · 2019Article
- Polarization wave at the onset of collective cell migration.Physical review. E · 2019Article
- Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases.Nature communications · 2019Article
- Article
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
- Fingering instabilities in tissue invasion: an active fluid model.Royal Society open science · 2018Article
- Article
- Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives.Nature communications · 2018Article
- Sharing and reusing cell image data.Molecular biology of the cell · 2018Article
- Low-level stretching accelerates cell migration into a gap.International wound journal · 2017Article
- Single and collective cell migration: the mechanics of adhesions.Molecular biology of the cell · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We find how collective migration emerges from mechanical information transfer between cells. Local alignment of cell velocity and mechanical stress orientation-a phenomenon dubbed "plithotaxis"-plays a crucial role in inducing coordinated migration. Leader cells at the monolayer edge better align velocity and stress to migrate faster toward the open space. Local seeds of enhanced motion then generate stress on neighboring cells to guide their migration. Stress-induced motion propagates into the monolayer as well as along the monolayer boundary to generate increasingly larger clusters of coordinately migrating cells that move faster with enhanced alignment of velocity and stress. Together, our analysis provides a model of long-range mechanical communication between cells, in which plithotaxis translates local mechanical fluctuations into globally collective migration of entire tissues.
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