Evidence map›Paper›PMID 26682757›Full record

Trial reportThe Journal of urology2016

Impact of Dry Mouth on Fluid Intake and Overactive Bladder Symptoms in Women taking Fesoterodine.

Steven J Weissbart, Rusell Lewis, Ariana L Smith, Heidi S Harvie, Janis M Miller, Lily A Arya

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Steven J WeissbartDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Steven.Weissbart@uphs.upenn.edu.
Rusell LewisPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Ariana L SmithDivision of Urology, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Heidi S HarvieDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
Janis M MillerDepartment of Health Behavior and Biological Sciences, School of Nursing, and Department of Obstetrics and Gynecology, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Lily A AryaDivision of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · USUniversity of Michigan–Ann Arbor · US

Funding

Pelvic Floor Disorders Network Clinical Sites (U10)U10HD069010 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ARYA, LILY A · 2011 to 2015
$1.7M
Neurogenic bladder dysfunctions in neurological disorders P20DK097819 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MALYKHINA, ANNA P · 2012 to 2013
$842k
NICHD NIH HHS U10 HD069010NIDDK NIH HHS P20 DK097819
6 · The paper itself

Abstract

purposeWe investigated the long-term relationships between dry mouth, fluid intake and overactive bladder symptoms in women undergoing treatment with fesoterodine. We hypothesized that women who experienced dry mouth would increase their fluid intake and worsen their urinary symptoms. MATERIALS AND

methodsWe conducted a prospective ancillary study to a 9-month open-label trial of fesoterodine for women with urgency urinary incontinence. Fluid intake was measured and compared according to reported dry mouth. Multivariable analysis was used to study the interaction between dry mouth, fluid intake and urinary symptoms.

resultsDuring the study 407 women without dry mouth significantly reduced their fluid intake (mean decrease 172.1 ml, median 118.3 ml, p = 0.02), while 91 women with dry mouth did not (mean decrease 95.8 ml, median 118.3 ml, p = 0.54). On univariable analysis a greater proportion of women who experienced dry mouth reported improvement in their urinary symptoms compared to women without dry mouth (60.5% vs 47.2%, p = 0.03). On multivariable analysis black women were less likely to report dry mouth (OR 0.4, 95% CI 0.2-0.9, p = 0.03) and older women were less likely to report improvement in urinary symptoms (OR 0.98, 95% CI 0.96-0.99, p = 0.003). Factors not associated with improvement in urinary symptoms on multiple regression were dry mouth, baseline fluid intake volume, change in fluid intake volume and caffeine intake volume.

conclusionsIn women with overactive bladder receiving fesoterodine dry mouth may prevent restriction of fluid intake but does not diminish treatment efficacy.

Indexed as

DrinkingBenzhydryl CompoundsDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansMiddle AgedMouth DiseasesMuscarinic AntagonistsProspective StudiesQuality of LifeSeverity of Illness IndexSurveys and QuestionnairesTime FactorsTreatment OutcomeUrinary Bladder, OveractiveBenzhydryl CompoundsfesoterodineMuscarinic Antagonistscaffeineurinary bladder, overactiveurinary incontinence, urgewater-electrolyte balancexerostomia

Identifiers

PMID26682757
PMCPMC4891185
OpenAlexW2194598637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.