ArticleeLife2015
Evidence for a common evolutionary rate in metazoan transcriptional networks.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evolutionary diversification of ancestral genes across vertebrates and insects.Genome biology · 2025Article
- Embryonic reprogramming of the tumor vasculature reveals targets for cancer therapy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- SAGA Complex Subunits inFrontiers in cellular and infection microbiology · 2022Article
- Functional signatures of evolutionarily young CTCF binding sites.BMC biology · 2020Article
- The Role of Chromatin Accessibility in cis-Regulatory Evolution.Genome biology and evolution · 2019Article
- Prediction of gene regulatory enhancers across species reveals evolutionarily conserved sequence properties.PLoS computational biology · 2018Article
- Robustness and evolvability of heterogeneous cell populations.Molecular biology of the cell · 2018Article
- Of mice, men and immunity: a case for evolutionary systems biology.Nature immunology · 2018Article
- ChIP-ping the branches of the tree: functional genomics and the evolution of eukaryotic gene regulation.Briefings in functional genomics · 2018Review
- Evolutionary Rewiring of Human Regulatory Networks by Waves of Genome Expansion.American journal of human genetics · 2018Article
- The rewiring of transcription circuits in evolution.Current opinion in genetics & development · 2017Review
- Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity.eLife · 2017Article
- How transcription circuits explore alternative architectures while maintaining overall circuit output.Genes & development · 2017Review
- Comparative transcriptomics in human and mouse.Nature reviews. Genetics · 2017Review
- Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species.Genome biology and evolution · 2017Article
- Gene discovery in amyotrophic lateral sclerosis: implications for clinical management.Nature reviews. Neurology · 2017Review
- Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic.Genome research · 2016Article
- Comparative Genomics: One for all.eLife · 2016Article
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7 authors.
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Abstract
Genome sequences diverge more rapidly in mammals than in other animal lineages, such as birds or insects. However, the effect of this rapid divergence on transcriptional evolution remains unclear. Recent reports have indicated a faster divergence of transcription factor binding in mammals than in insects, but others found the reverse for mRNA expression. Here, we show that these conflicting interpretations resulted from differing methodologies. We performed an integrated analysis of transcriptional network evolution by examining mRNA expression, transcription factor binding and cis-regulatory motifs across >25 animal species, including mammals, birds and insects. Strikingly, we found that transcriptional networks evolve at a common rate across the three animal lineages. Furthermore, differences in rates of genome divergence were greatly reduced when restricting comparisons to chromatin-accessible sequences. The evolution of transcription is thus decoupled from the global rate of genome sequence evolution, suggesting that a small fraction of the genome regulates transcription.
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