ArticleInternational journal of ophthalmology2015
Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas: a retrospective cohort study.
Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
- Decoding visual pathway damage in pituitary macroadenomas: insights from retinal nerve fiber layer and visual field analysis.International ophthalmology · 2026Article
- A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study.Frontiers in endocrinology · 2024Article
- Microvascular Changes in Pituitary Adenoma Correlate with Structural Measurements and Visual Field Loss.Neuropsychiatric disease and treatment · 2023Article
- Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma.Frontiers in oncology · 2023Article
- Predictive value of retinal nerve fibre layer thickness for postoperative visual improvement in patients with pituitary macroadenoma.BMJ open ophthalmology · 2022Observational
- Parafoveal and peripapillary vessel density in pediatric and juvenile craniopharyngioma patients.Scientific reports · 2022Article
- Machine Learning Prediction of Visual Outcome after Surgical Decompression of Sellar Region Tumors.Journal of personalized medicine · 2022Article
- Bi-nasal sectors of ganglion cells complex and visual evoked potential amplitudes as biomarkers in pituitary macroadenoma management.Frontiers in integrative neuroscience · 2022Article
- Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas: Our Institutional Experience.Journal of neurological surgery. Part B, Skull base · 2021Article
- Analysis of factors affecting visual field recovery following surgery for pituitary adenoma.International ophthalmology · 2021Article
- Optical Coherence Tomography Angiography Predicts Visual Outcomes for Craniopharyngioma in Children by Quantifying Choroidal Capillaries.Frontiers in medicine · 2021Article
- Rapid visual field constriction in a patient with retinitis pigmentosa and pituitary adenoma.American journal of ophthalmology case reports · 2020Article
- Parafoveal and Peripapillary Perfusion Predict Visual Field Recovery in Chiasmal Compression due to Pituitary Tumors.Journal of clinical medicine · 2020Article
- Preoperative visual evoked potential in the prediction of visual outcome after pituitary macroadenomas surgery.Pituitary · 2019Article
- Factors Influencing Visual Field Recovery after Transsphenoidal Resection of a Pituitary Adenoma.Korean journal of ophthalmology : KJO · 2018Article
- Visual Outcomes after Endoscopic Pituitary Surgery in Patients Presenting with Preoperative Visual Deficits.Journal of neurological surgery. Part B, Skull base · 2017Article
- Predictive value of preoperative retinal nerve fiber layer thickness for postoperative visual recovery in patients with chiasmal compression.Oncotarget · 2017Article
- Efficacy of sellar opening in the pituitary adenoma resection of transsphenoidal surgery influences the degree of tumor resection.BMC medical imaging · 2017Article
- Predictive factors of visual function recovery after pituitary adenoma resection: a literature review and Meta-analysis.International journal of ophthalmology · 2017Article
- Predictive model for recovery of visual field after surgery of pituitary adenoma.Journal of neuro-oncology · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas.
methodsThis retrospective cohort study included 201 patients (366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best-corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation (MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor (VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique.
resultsThe mean age of patients was 44.23±1.29y. Ninety-three patients were female and 108 were male. The mean tumor volume was 14.36±6.23 cm(3). The mean duration of preoperative symptoms was 11.50±0.88mo. Mean preoperative MD was -17.50±0.82 dB. Mean Preoperative visual acuity was 0.64±0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative MD absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of tumor (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of VEGF in tumor tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in tumor tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026).
conclusionAfter pituitary macroadenomas trans-sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative MD absolute value, young age, small volume of tumor, and expression levels of VEGF/ Ki-67.
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