ArticleInternational journal of ophthalmology2015
Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population.
Article in International journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Review
- Association of eleven single nucleotide polymorphisms with refractive disorders from Eskisehir, Turkey.International journal of ophthalmology · 2021Article
- Mitochondrial Dynamics Related Genes -Pharmacogenomics and personalized medicine · 2021Article
- IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- The investigation on the role of mitochondrial fusion protein 1 in the development of myopia.Indian journal of ophthalmology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population.
methodsThe case-control association analysis was used. The study included 100 independent myopia patients (-0.75 D ≤ spherical refraction ≤-8.00 D) and 100 sex-matched healthy controls (with binocular spherical equivalent ranges between -0.50 D and +0.50 D). Four single nucleotide polymorphism (SNP) tags (rs3976523, rs13098637, rs6762399 and rs7618348) were selected for genotyping by direct sequencing. The frequencies of genotypes and their alleles were calculated based on the number of SNP genotypes in each sample. The Chi-square test was used to examine the difference in the frequency between the myopia cases and controls.
resultsGenotype distributions in the four SNPs were all in accordance with the Hardy-Weinberg equilibrium; analysis showed that rs13098637 was significantly associated with low to moderate myopia (P=0.003 and empirical P=0.010). There were no statistically significant differences observed for the genotype or allele frequencies of the other three SNPs between the myopia cases and controls in the Chinese population in this study.
conclusionThe current study has revealed that the C allele of rs13098637 in MFN1 had a significant association with low to moderate myopia.
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