ArticleOxidative medicine and cellular longevity2016
Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- The renoprotective effect of d-limonene against cisplatin-induced acute kidney injury: targeting Nrf2/HO-1 and NLRP-3 inflammasome signaling pathways.Molecular and cellular biochemistry · 2026Article
- An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α.Molecular and cellular biochemistry · 2024Review
- Article
- Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation.Aging · 2022Article
- D-limonene (5 (one-methyl-four-[1-methylethenyl]) cyclohexane) diminishes CClRedox report : communications in free radical research · 2022Article
- Antibacterial and Oxidative Stress-Protective Effects of Five Monoterpenes from Softwood.Molecules (Basel, Switzerland) · 2022Article
- A Comparative Study on Relieving Exercise-Induced Fatigue by Inhalation of Different Citrus Essential Oils.Molecules (Basel, Switzerland) · 2022Article
- Review
- Retracted: Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway.Oxidative medicine and cellular longevity · 2022Article
- Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Article
- Myocardial Infarction-Associated Extracellular Vesicle-Delivered miR-208b Affects the Growth of Human Umbilical Vein Endothelial Cells via Regulating CDKN1A.BioMed research international · 2021Article
- D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF-Oxidative medicine and cellular longevity · 2021Article
- Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves ofMolecules (Basel, Switzerland) · 2020Article
- Long non-coding RNA nuclear paraspeckle assembly transcript 1 protects human lens epithelial cells against HAnnals of translational medicine · 2020Article
- Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review.International journal of environmental research and public health · 2020Review
- D-Limonene mitigate myocardial injury in rats through MAPK/ERK/NF-κB pathway inhibition.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases.International journal of molecular sciences · 2020Review
- Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders.Clinical, cosmetic and investigational dermatology · 2020Review
- Ethylene glycol coated nanoceria protects against oxidative stress in human lens epithelium.RSC advances · 2019Article
Corrections and comments
- Retraction · 2022-05-29Duplication of/in Image · Error in Image · Euphemisms for Duplication · Investigation by Third Party · · see also: https://pubpeer.com/publications/AECE178709696FE893E0F06E261D86
- Retracted
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress, as mediated by ROS, is a significant factor in initiating the development of age-associated cataracts; D-limonene is a common natural terpene with powerful antioxidative properties which occurs naturally in a wide variety of living organisms. It has been shown to have antioxidant effect; we found that D-limonene can effectively prevent the oxidative damage caused by H2O2 and propose that the main mechanism underlying the inhibitory effects of D-limonene is the inhibition of HLECs apoptosis. In the present study, we used confocal-fluorescence microscopy, flow cytometry analysis, Hoechst staining, H2DCFDA staining, transmission electron microscopy, and immunoblot analysis; the results revealed that slightly higher concentrations of D-limonene (125-1800 μM) reduced the H2O2-induced ROS generation and inhibited the H2O2-induced caspase-3 and caspase-9 activation and decreased the Bcl-2/Bax ratio. Furthermore, it inhibited H2O2-induced p38 MAPK phosphorylation. Thus, we conclude that D-limonene could effectively protect HLECs from H2O2-induced oxidative stress and that its antioxidative effect is significant, thereby increasing the cell survival rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.