Evidence map›Paper›PMID 26681999›Full record

ArticleThe World Allergy Organization journal2015

Urticaria as initial finding of a patient with carcinoid tumor.

Ivan Cherrez Ojeda, Juan Carlos Calderon, Karin Plaza, Emanuel Vanegas, Annia Cherrez, José Cano

Open access · goldAbstract readCase Reports
In one paragraph

Article in The World Allergy Organization journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Itch: Epidemiology, clinical presentation, and diagnostic workup.Journal of the American Academy of Dermatology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ivan Cherrez OjedaUniversidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador ; Respiralab Research Group, Clínica Kennedy, Guayaquil, Ecuador.
Juan Carlos CalderonUniversidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador ; Respiralab Research Group, Clínica Kennedy, Guayaquil, Ecuador.
Karin PlazaUniversidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador.
Emanuel VanegasUniversidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador.
Annia CherrezRespiralab Research Group, Clínica Kennedy, Guayaquil, Ecuador ; University of Heidelberg, School of Medicine, Heidelberg, Germany.
José CanoUniversidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador.
Universidad de Especialidades Espíritu Santo · ECHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTypical carcinoid syndrome is characterized by flushing, abdominal pain and diarrhea and occurs in <10 % of carcinoid tumor patients. Very rarely, initial signs include skin manifestations. Our purpose is to highlight cutaneous manifestations in the diagnosis and assessment of a patient with atypical manifestation of type I gastric carcinoid tumor. CASE PRESENTATION: A 50-year-old woman presented with anemia, chronic urticaria and angioedema. Urticaria was triggered principally by seafood and appeared in the first hour after. Urticaria Activity Score 7 was 24, and quality of life (CU-Q2oL) was 3.61. P. Laboratory findings showed anemia, diminished iron, ferritin, and vitamin B12, with increased gastrin and anti-parietal cell antibody levels. 15 gastric carcinoids 5 mm in diameter were observed in the greater curvature of the stomach during gastric endoscopy and confirmed by biopsy, suggesting that this patient had type I gastric carcinoids. Four additional tumors were found in the small intestine upon examination via video capsule. Endoscopic argon plasma therapy was performed. The patient experienced definitive improvement in quality of life and urticaria activity score.

conclusionThis patient, whose principal symptoms were anemia, urticaria and angioedema, was found to have atypical carcinoid syndrome, with tumors located in the stomach. Allergists, immunologists, internists and primary care physicians should consider the possibility of neuroendocrine malignancies, specifically type I carcinoid tumors, when evaluating patients with urticaria, and consider screening patients with chronic urticaria for elevated anti-parietal cell antibody levels.

Indexed as

AntibodiesCarcinoid tumorsEnterochromaffin cellsKininQuality of lifeSerotoninUrticaria

Identifiers

PMID26681999
PMCPMC4675029
OpenAlexW2193858048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.