Evidence map›Paper›PMID 26681831›Full record

ArticleBiology of sport2015

Long-term treadmill exercise improves spatial memory of male APPswe/PS1dE9 mice by regulation of BDNF expression and microglia activation.

J Y Xiong, S C Li, Y X Sun, X S Zhang, Z Z Dong, P Zhong, X R Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sport, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
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  17. Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  18. Article
  19. Review
  20. Physical exercise prevents amyloid βMetabolic brain disease · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J Y XiongSchool of Physical Education, Lingnan Normal University, Zhanjiang 524048, China ; Equal contribution.
S C LiSchool of Physical Education, Lingnan Normal University, Zhanjiang 524048, China ; Equal contribution.
Y X SunLibrary of Mudanjiang Medical University, Mudanjiang 157011, China ; Equal contribution.
X S ZhangSchool of Physical Education, Lingnan Normal University, Zhanjiang 524048, China ; Equal contribution.
Z Z DongThe Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325200, China.
P ZhongLaboratory of Physiological Science, Guangdong Medical University, Dongguan 523808, China.
X R SunKey Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China ; Institute of Aging Research, Dongguan Scientific Center, Guangdong Medical University, Dongguan 523808, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests that physical activity could delay or attenuate the symptoms of Alzheimer's disease (AD). But the underlying mechanisms are still not fully understood. To investigate the effect of long-term treadmill exercise on the spatial memory of AD mice and the possible role of β-amyloid, brain-derived neurotrophic factor (BDNF) and microglia in the effect, male APPswe/PS1dE9 AD mice aged 4 months were subjected to treadmill exercise for 5 months with 6 sessions per week and gradually increased load. A Morris water maze was used to evaluate the spatial memory. Expression levels of β-amyloid, BDNF and Iba-1 (a microglia marker) in brain tissue were detected by immunohistochemistry. Sedentary AD mice and wildtype C57BL/6J mice served as controls. The results showed that 5-month treadmill exercise significantly decreased the escape latencies (P < 0.01 on the 4th day) and improved the spatial memory of the AD mice in the water maze test. Meanwhile, treadmill exercise significantly increased the number of BDNF-positive cells and decreased the ratios of activated microglia in both the cerebral cortex and the hippocampus. However, treadmill exercise did not significantly alleviate the accumulation of β-amyloid in either the cerebral cortex or the hippocampus of the AD mice (P > 0.05). The study suggested that long-term treadmill exercise could improve the spatial memory of the male APPswe/PS1dE9 AD mice. The increase in BDNF-positive cells and decrease in activated microglia might underpin the beneficial effect.

Indexed as

Alzheimer's diseasebrain-derived neurotrophicexercisefactormicemicroglia

Identifiers

PMID26681831
PMCPMC4672160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.