Evidence map›Paper›PMID 26681727›Full record

SynthesisDiabetes care2016

Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.

Saion Chatterjee, Sanne A E Peters, Mark Woodward, Silvia Mejia Arango, G David Batty, Nigel Beckett, Alexa Beiser, Amy R Borenstein, Paul K Crane, Mary Haan and 14 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 376 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 6 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 6 syntheses or guidelines pooled it, 688 citations in OpenAlex.

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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 9 countries.

Saion ChatterjeeAlfred Health, Melbourne, Australia.
Sanne A E PetersThe George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
Mark WoodwardThe George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, Oxford, U.K. The George Institute for Global Health, University of Sydney, Sydney, Australia Department of Epidemiology, Johns Hopkins University, Baltimore, MD.
Silvia Mejia ArangoDepartment of Population Studies, El Colegio de la Frontera Norte, Tijuana, Baja California, México.
G David BattyDepartment of Epidemiology and Public Health, University College London, London, U.K. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, U.K. Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, U.K.
Nigel BeckettSection of Care of the Elderly, Faculty of Medicine, Imperial College London, London, U.K.
Alexa BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Amy R BorensteinDepartment of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA.
Mary HaanDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Linda B HassingDepartment of Psychology, Gothenburg University, Gothenburg, Sweden.
Kathleen M HaydenDepartment of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC.
Yutaka KiyoharaDepartment of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Eric B LarsonGroup Health Research Institute, Seattle, WA.
Chung-Yi LiDepartment and Graduate Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Tawian.
Toshiharu NinomiyaDepartment of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tomoyuki OharaDepartment of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ruth PetersSection of Care of the Elderly, Faculty of Medicine, Imperial College London, London, U.K.
Tom C RussCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, U.K. Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, U.K. Scottish Dementia Clinical Research Network, NHS Scotland, Edinburgh, U.K. Division of Psychiatry, The University of Edinburgh, Edinburgh, U.K.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, MA.
Bjørn H StrandNorwegian Institute of Public Health, Oslo, Norway.
Rod WalkerGroup Health Research Institute, Seattle, WA.
Weili XuAging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institute and Stockholm University, Stockholm, Sweden School of Public Health, Tianjin Medical University, Tianjin, China.
Rachel R HuxleyThe George Institute for Global Health, University of Sydney, Sydney, Australia School of Public Health, Curtin University, Perth, Australia rachel.huxley@curtin.edu.au.
Kyushu University · JPBoston University · USKaiser Permanente Washington Health Research Institute · USAlfred Health · AUEl Colegio de la Frontera Norte · MXNational Cheng Kung University · TWNorwegian Institute of Public Health · NOStockholm University · SEThe George Institute for Global Health · AUUniversity College London · GBUniversity of California, San Francisco · USUniversity of Gothenburg · SEUniversity of South Florida · USUniversity of Sydney · AUUniversity of Washington · USWake Forest University · US

Funding

Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N · 1997 to 2015
$13.8M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Diabetes in older Latinos, stress and brain changesR01DK060753 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N. · 2002 to 2004
$1.4M
EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANSR01AG009769 · NIA · UNIVERSITY OF WASHINGTON · PI LARSON, ERIC B · 1991 to 2000
$1.1M
Medical Research Council MR/K026992/1NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNIA NIH HHS AG-006781NIA NIH HHS AG-09769NIA NIH HHS AG-12975NIA NIH HHS R01 AG012975NIA NIH HHS U01 AG006781NIDDK NIH HHS DK-60753NIDDK NIH HHS R01 DK060753
6 · The paper itself

Abstract

objectiveType 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. RESEARCH DESIGN AND

methodsA systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses.

resultsStudy-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P < 0.001).

conclusionsIndividuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.

Indexed as

AgedAged, 80 and overDementiaDementia, VascularDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSex Factors

Identifiers

PMID26681727
PMCPMC4722942
OpenAlexW2211614117

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.