ArticleDiabetes care2016
A1C Combined With Glycated Albumin Improves Detection of Prediabetes in Africans: The Africans in America Study.
Article in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.Pediatric diabetes · 2019Trial
- Prediabetes.Nature reviews. Disease primers · 2025Review
- Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices.Communications medicine · 2025Article
- Liquid Biopsy: A Game Changer for Type 2 Diabetes.International journal of molecular sciences · 2024Review
- Advances in electrochemical biosensors employing carbon-based electrodes for detection of biomarkers in diabetes mellitus.ADMET & DMPK · 2024Review
- Usefulness of glycated albumin level as a glycemic index complementing glycosylated hemoglobin in diabetic children and adolescents.Annals of pediatric endocrinology & metabolism · 2023Article
- Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Early detection of type 2 diabetes risk: limitations of current diagnostic criteria.Frontiers in endocrinology · 2023Article
- Waist circumference and glycaemia are strong predictors of progression to diabetes in individuals with prediabetes in sub-Saharan Africa: 4-year prospective cohort study in Malawi.PLOS global public health · 2023Article
- Prevalence of haemoglobin A1c based dysglycaemia among adult community dwellers in selected states in Nigeria: a descriptive cross-sectional study.Frontiers in endocrinology · 2023Article
- Combining HbAEClinicalMedicine · 2022Article
- Serum fructosamine and glycemic status in the presence of the sickle cell mutation.Diabetes research and clinical practice · 2021Article
- Factors associated with glycated albumin in adults without diabetes.Medicine and pharmacy reports · 2021Article
- HbAPreventing chronic disease · 2021Article
- Recent Updates and Advances in the Use of Glycated Albumin for the Diagnosis and Monitoring of Diabetes and Renal, Cerebro- and Cardio-Metabolic Diseases.Journal of clinical medicine · 2020Review
- Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities.Paediatric drugs · 2020Review
- A1C Underperforms as a Diagnostic Test in Africans Even in the Absence of Nutritional Deficiencies, Anemia and Hemoglobinopathies: Insight From the Africans in America Study.Frontiers in endocrinology · 2019Article
- Reduced plasma albumin predicts type 2 diabetes and is associated with greater adipose tissue macrophage content and activation.Diabetology & metabolic syndrome · 2019Article
- Article
- Haemoglobin A1c or Glycated Albumin for Diagnosis and Monitoring Diabetes: An African Perspective.Indian journal of clinical biochemistry : IJCB · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveSlowing the diabetes epidemic in Africa requires improved detection of prediabetes. A1C, a form of glycated hemoglobin A, is recommended for diagnosing prediabetes. The glycated proteins, fructosamine and glycated albumin (GA), are hemoglobin-independent alternatives to A1C, but their efficacy in Africans is unknown. Our goals were to determine the ability of A1C, fructosamine, and GA to detect prediabetes in U.S.-based Africans and the value of combining A1C with either fructosamine or GA. RESEARCH DESIGN AND
methodsOral glucose tolerance tests (OGTT) were performed in 217 self-identified healthy African immigrants (69% male, age 39 ± 10 years [mean ± SD], BMI 27.6 ± 4.5 kg/m(2)). A1C, fructosamine, and GA were measured. Prediabetes was diagnosed by American Diabetes Association criteria for glucose obtained from a 2-h OGTT. The thresholds to diagnose prediabetes by A1C, fructosamine, and GA were the cutoff at the upper tertile for each variable: ≥5.7% (39 mmol/mol) (range 4.2-6.6% [22.4-48.6 mmol/mol]), ≥230 µmol/L (range 161-269 µmol/L), and ≥13.35% (range 10.20-16.07%), respectively.
resultsPrediabetes occurred in 34% (74 of 217). The diagnostic sensitivities of A1C, fructosamine, and GA were 50%, 41%, and 42%, respectively. The P values for comparison with A1C were both >0.3. Combining A1C with either fructosamine or GA increased sensitivities. However, the sensitivity of A1C combined with fructosamine was not better than for A1C alone (72% vs. 50%, P = 0.172). In contrast, the sensitivity of A1C combined with GA was higher than for A1C alone (78% vs. 50%, P < 0.001).
conclusionsAs individual tests, A1C, fructosamine, and GA detected ≤50% of Africans with prediabetes. However, combining A1C with GA made it possible to identify nearly 80% of Africans with prediabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.