ArticleScientific reports2015
Compact Wireless Microscope for In-Situ Time Course Study of Large Scale Cell Dynamics within an Incubator.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- zIncubascope: Long-term quantitative imaging of multi-cellular assemblies inside an incubator.PloS one · 2025Article
- COMethods and protocols · 2024Article
- Noninvasive total counting of cultured cells using a home-use scanner with a pattern sheet.iScience · 2024Article
- Implementation of miniaturized modular-array fluorescence microscopy for long-term live-cell imaging.Applied optics · 2023Article
- TheRoyal Society open science · 2022Article
- Simultaneous Detection of Viability and Concentration of Microalgae Cells Based on Chlorophyll Fluorescence and Bright Field Dual Imaging.Micromachines · 2021Article
- The incubot: A 3D printer-based microscope for long-term live cell imaging within a tissue culture incubator.HardwareX · 2021Article
- Miniaturized modular-array fluorescence microscopy.Biomedical optics express · 2020Article
- Low-cost calcium fluorometry for long-term nanoparticle studies in living cells.Scientific reports · 2020Article
- Large scale and integrated platform for digital mass culture of anchorage dependent cells.Nature communications · 2019Article
- Large field-of-view phase and fluorescence mesoscope with microscopic resolution.Journal of biomedical optics · 2019Article
- Article
- Highly sensitive lens-free fluorescence imaging device enabled by a complementary combination of interference and absorption filters.Biomedical optics express · 2018Article
- MBiosensors & bioelectronics · 2018Article
- Flatbed epi relief-contrast cellular monitoring system for stable cell culture.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging of live cells in a region of interest is essential to life science research. Unlike the traditional way that mounts CO2 incubator onto a bulky microscope for observation, here we propose a wireless microscope (termed w-SCOPE) that is based on the "microscope-in-incubator" concept and can be easily housed into a standard CO2 incubator for prolonged on-site observation of the cells. The w-SCOPE is capable of tunable magnification, remote control and wireless image transmission. At the same time, it is compact, measuring only ~10 cm in each dimension, and cost-effective. With the enhancement of compressive sensing computation, the acquired images can achieve a wide field of view (FOV) of ~113 mm(2) as well as a cellular resolution of ~3 μm, which enables various forms of follow-up image-based cell analysis. We performed 12 hours time-lapse study on paclitaxel-treated MCF-7 and HEK293T cell lines using w-SCOPE. The analytic results, such as the calculated viability and therapeutic window, from our device were validated by standard cell detection assays and imaging-based cytometer. In addition to those end-point detection methods, w-SCOPE further uncovered the time course of the cell's response to the drug treatment over the whole period of drug exposure.
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