Evidence map›Paper›PMID 26681359›Full record

ReviewTropical medicine & international health : TM & IH2016

Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges.

Rashida A Ferrand, Datonye Briggs, Jane Ferguson, Martina Penazzato, Alice Armstrong, Peter MacPherson, David A Ross, Katharina Kranzer

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tropical medicine & international health : TM & IH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438370 (Outcomes of Differentiated Models of Antiretroviral Treatment), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438370 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision: Multi-Month Dispensing (MMD) of ART in Community ART Distribution for Stable HIV Infected Patients

TypeinterventionalSponsorEquip, LesothoRan2017 to 2019Enrolled5,760ConditionsHIV/AIDSArmsThree monthly ART supply at CAGs, Six monthly ART supply at outreaches
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  18. Phenylketonuria as an Adherence Disease.Patient preference and adherence · 2025
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Rashida A FerrandLondon School of Hygiene and Tropical Medicine, London, UK.
Datonye BriggsLondon School of Hygiene and Tropical Medicine, London, UK.
Jane FergusonWorld Health Organization, Geneva, Switzerland.
Martina PenazzatoWorld Health Organization, Geneva, Switzerland.
Alice ArmstrongWorld Health Organization, Geneva, Switzerland.
Peter MacPhersonDepartment of Public Health and Policy, University of Liverpool, Liverpool, UK.
David A RossLondon School of Hygiene and Tropical Medicine, London, UK.
Katharina KranzerLondon School of Hygiene and Tropical Medicine, London, UK.
London School of Hygiene & Tropical Medicine · GBWorld Health Organization · CHUniversity of Liverpool · GB

Funding

Wellcome Trust 095878World Health Organization 001
6 · The paper itself

Abstract

objectiveMedication adherence is often suboptimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion of adolescents achieving virological suppression after initiating ART.

methodsMEDLINE, EMBASE and Web of Science databases were searched. Studies published between January 2004 and September 2014 including ≥50 adolescents taking ART and reporting on the proportion of virological suppressed participants were included.

resultsFrom a total of 5316 potentially relevant citations, 20 studies were included. Only eight studies reported the proportion of adolescents that were virologically suppressed at a specified time point. The proportion of adolescents with virological suppression at 12 months ranged from 27 to 89%.

conclusionAdolescent achievement of HIV virological suppression was highly variable. Improved reporting of virological outcomes from a wider range of settings is required to support efforts to improve HIV care and treatment for adolescents.

Indexed as

AdolescentAnti-HIV AgentsHIV InfectionsHumansMedication AdherenceTreatment OutcomeViral LoadAnti-HIV AgentsAdolescentesadolescentsAdolescentsHIVsuppression virologiquesupresión virológicaVIHvirological suppression

Identifiers

PMID26681359
PMCPMC4776345
OpenAlexW2275808657

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.