Evidence map›Paper›PMID 26681241›Full record

ArticleAIDS research and human retroviruses2016

Monitoring HIV-1 Group M Subtypes in Yaoundé, Cameroon Reveals Broad Genetic Diversity and a Novel CRF02_AG/F2 Infection.

Colleen R Courtney, Lucy Agyingi, Arlette Fokou, Stephanie Christie, Bladine Asaah, Josephine Meli, Johnson Ngai, Indira Hewlett, Phillipe N Nyambi

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  8. Primary resistance to antiretroviral drugs of HIV strains in Chad: a retrospective investigation by analysis of frozen dried blood spot samples.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Colleen R Courtney1 Department of Microbiology, New York University School of Medicine , New York, New York.
Lucy Agyingi2 Faculty of Science, University of Dschang , Dschang, Cameroon .
Arlette Fokou4 School of Laboratory Technicians , Yaoundé, Cameroon .
Stephanie Christie5 Department of Biophysics and Systems Pharmacology, Icahn School of Medicine Mount Sinai , New York, New York.
Bladine Asaah3 Medical Diagnostic Center , Yaoundé, Cameroon .
Josephine Meli3 Medical Diagnostic Center , Yaoundé, Cameroon .
Johnson Ngai3 Medical Diagnostic Center , Yaoundé, Cameroon .
Indira Hewlett7 Laboratory of Molecular Virology, Division of Emerging and Transmission Transmitted Diseases, Office of Blood Review and Research, Center for Biologics Evaluation and Research , Food and Drug Administration, Silver Spring, Maryland.
Phillipe N Nyambi8 Department of Pathology, New York University School of Medicine , New York, New York.

Funding

SUPPLEMENT FOR MARC SCIENTIFIC COMMUNICATIONS TECHNOLOGYT34GM008078 · NIGMS · BROOKLYN COLLEGE · PI HAINLINE, LOUISE, RABIN, LAURA A. · 1985 to 2022
$8.2M
Viral Evolution and Humoral Immune Response to Dual HIV-1 InfectionR01AI083142 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORNY, MIROSLAW K · 2010 to 2015
$2.6M
Improving Research Capacity in Cameroon for Studies on HIV-Associated MalignanciesD43CA153726 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NYAMBI, PHILLIPE N · 2010 to 2014
$2.0M
Training Program on HIV Diversity and Drug Resistance-Enhancing Research CapacityD43TW009604 · FIC · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORNY, MIROSLAW K · 2013 to 2017
$1.4M
Viral Evolution and Humoral Immune Response to Dual HIV-1 InfectionR56AI083142 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NYAMBI, PHILLIPE N · 2009 to 2009
$407k
FIC NIH HHS D43 TW009604FIC NIH HHS TW009604NCI NIH HHS CA153726NIAID NIH HHS AI07647NIAID NIH HHS AI083142NIAID NIH HHS R01 AI083142
6 · The paper itself

Abstract

Broad HIV-1 genetic diversity in Cameroon provides a unique opportunity to monitor HIV-1 evolution and allows the detection of novel strains. We have genetically characterized the HIV-1 subtypes found in 156 samples from 90 drug-naive subjects in Yaoundé, Cameroon collected from 2011 to 2013, using phylogenetic analysis of regions in gag and pol. We identified subtypes CRF02_AG (64.9%), CRF22_01A1 (7.1%), D (4.5%), F2 (3.9%), G (3.2%), CRF18_cpx (3.2%), CRF37_cpx (3.2%), CRF11_cpx (2.6%), CRF13_cpx (1.9%), A1 (1.3%), CRF01_AE (1.3%), CRF09_cpx (1.3%), A2 (0.6%), and H (0.6%). Sequence data for both the gag and pol regions were obtained from 62 subjects; for 59 of these subjects the two regions were identified as the same viral subtype while three subjects were discordant, A1/CRF02_AG (subject MDC006), CRF02_AG/F2 (subject MDC179), and a dual infection with CRF02_AG/F2 (subject MDC131). Longitudinal sequence data were obtained for 28 of these 62 subjects and confirmed the cross-sectional results. These data update subtype information for this area and highlight the necessity of such studies due to the numerous circulating subtypes, the ongoing superinfection, and the risk of emerging novel recombinant viruses.

Indexed as

Genetic VariationGenotypeAdultCameroonCross-Sectional StudiesFemalegag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedMolecular Epidemiologypol Gene Products, Human Immunodeficiency VirusSequence Analysis, DNAgag Gene Products, Human Immunodeficiency Viruspol Gene Products, Human Immunodeficiency Virus

Identifiers

PMID26681241
PMCPMC4817561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.