Evidence map›Paper›PMID 26681237›Full record

ArticleInternational journal of psychiatry in medicine

Predictors of psychotropic medication adherence among HIV+ individuals living with bipolar disorder.

Kaitlin B Casaletto, Sara Kwan, Jessica L Montoya, Lisa C Obermeit, Ben Gouaux, Amelia Poquette, Robert K Heaton, J Hampton Atkinson, David J Moore, HNRP Group

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of psychiatry in medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. HIV and ageing: improving quantity and quality of life.Current opinion in HIV and AIDS · 2016
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kaitlin B CasalettoSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Sara KwanDepartment of Psychology, University of Chicago, Chicago, IL, USA.
Jessica L MontoyaSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Lisa C ObermeitSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Ben GouauxDepartment of Psychiatry, University of San Diego, CA, USA.
Amelia PoquetteDepartment of Psychiatry, University of San Diego, CA, USA.
Robert K HeatonDepartment of Psychiatry, University of San Diego, CA, USA.
J Hampton AtkinsonDepartment of Psychiatry, University of San Diego, CA, USA VA San Diego Healthcare System, San Diego, CA, USA.
David J MooreDepartment of Psychiatry, University of San Diego, CA, USA djmoore@ucsd.edu.
HNRP Group
University of San Diego · USSan Diego State University · USUniversity of Chicago · USVA San Diego Healthcare System · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
A Metacognition-based Approach to Improve HAND Among Methamphetamine UsersF31DA035708 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CASALETTO, KAITLIN B · 2013 to 2015
$99k
NIDA NIH HHS F31 DA035708NIDA NIH HHS T32 DA031098NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

objectiveHIV infection and bipolar disorder are highly comorbid and associated with frontostriatal disruption, emotional dysregulation, and neurocognitive impairment. Psychiatric and cognitive factors have been linked to antiretroviral nonadherence; however, predictors of psychotropic adherence among HIV+ individuals with psychiatric comorbidities have not been explored. We evaluated predictors of psychotropic adherence among individuals with HIV infection and bipolar disorder.

methodPsychiatric medication adherence of 50 participants with HIV infection and bipolar disorder was tracked for 30 days using Medication Event Monitoring Systems. Participants completed neurocognitive, neuromedical, and psychiatric batteries.

resultsMean psychotropic adherence rate was 78%; 56% of participants achieved ≥90% adherence. Younger age and onset of depressive symptoms, more severe current depressive symptoms, number of previous psychiatric hospitalizations and suicide attempts, poorer neurocognition, and more negative attitudes and self-beliefs toward medications univariably predicted worse psychotropic adherence (p's < .10). A multivariable model demonstrated a combination of current depressive symptoms and more negative attitudes toward medications significantly predicting poorer adherence (R(2 )= 0.27, p < 0.003). Secondary analyses revealed an interaction between neurocognition and mood, such that individuals with HIV infection and bipolar disorder who had greater executive dysfunction and depressive symptoms evidenced the poorest psychotropic adherence (p < 0.001).

conclusionsBoth psychiatric and neurocognitive factors contribute to poorer psychotropic adherence among HIV+ individuals with serious mental illness. Adherence interventions aimed at remediating these factors may be especially fruitful.

Indexed as

AdultBipolar DisorderCohort StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedPsychotropic DrugsPsychotropic DrugsattitudecognitionComorbiditydepression

Identifiers

PMID26681237
PMCPMC5154732
OpenAlexW2414130150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.