Evidence map›Paper›PMID 26681190›Full record

ArticlePloS one2015

Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population.

Ping Xue, Lin Gao, Sha Xiao, Guopei Zhang, Mingyang Xiao, Qianye Zhang, Xiao Zheng, Yuan Cai, Cuihong Jin, Jinghua Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ping XueDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Lin GaoDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Sha XiaoDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Guopei ZhangDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Mingyang XiaoDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Qianye ZhangDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Xiao ZhengDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Yuan CaiDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Cuihong JinDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Jinghua YangDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Shengwen WuDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
Xiaobo LuDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P.R. China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIndividual variations in the capacity of DNA repair machinery to relieve benzene-induced DNA damage may be the key to developing chronic benzene poisoning (CBP), an increasingly prevalent occupational disease in China. ERCC1 (Excision repair cross complementation group 1) is located on chromosome 19q13.2-3 and participates in the crucial steps of Nucleotide Excision Repair (NER); moreover, we determined that one of its polymorphisms, ERCC1 rs11615, is a biomarker for CBP susceptibility in our previous report. Our aim is to further explore the deeper association between some genetic variations related to ERCC1 polymorphisms and CBP risk.

methodsNine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma pigmentosum group B), XPC (Xeroderma pigmentosum group C) and XPF (Xeroderma pigmentosum group F) were genotyped by the Snapshot and TaqMan-MGB® probe techniques, in a study involving 102 CBP patients and 204 controls. The potential interactions between these SNPs and lifestyle factors, such as smoking and drinking, were assessed using a stratified analysis.

resultsAn XRCC1 allele, rs25487, was related to a higher risk of CBP (P<0.001) even after stratifying for potential confounders. Carriers of the TT genotype of XRCC1 rs1799782 who were alcohol drinkers (OR = 8.000; 95% CI: 1.316-48.645; P = 0.022), male (OR = 9.333; 95% CI: 1.593-54.672; P = 0.019), and had an exposure of ≤12 years (OR = 2.612; 95% CI: 1.048-6.510; P = 0.035) had an increased risk of CBP. However, the T allele in PPP1R13L rs1005165 (P<0.05) and the GA allele in CD3EAP rs967591 (OR = 0.162; 95% CI: 0039~0.666; P = 0.037) decreased the risk of CBP in men. The haplotype analysis of XRCC1 indicated that XRCC1 rs25487A, rs25489G and rs1799782T (OR = 15.469; 95% CI: 5.536-43.225; P<0.001) were associated with a high risk of CBP.

conclusionsThe findings showed that the rs25487 and rs1799782 polymorphisms of XRCC1 may contribute to an individual's susceptibility to CBP and may be used as valid biomarkers. Overall, the genes on chromosome 19q13.2-3 may have a special significance in the development of CBP in occupationally exposed Chinese populations.

Indexed as

Genetic Predisposition to DiseaseOccupational ExposurePolymorphism, GeneticAdolescentAdultBenzeneCase-Control StudiesChinaDNA-Binding ProteinsDNA HelicasesFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedPoisoningBenzeneDNA-Binding ProteinsDNA HelicasesIntracellular Signaling Peptides and ProteinsPOLR1G protein, humanPPP1R13L protein, humanRepressor ProteinsRNA Polymerase Ixeroderma pigmentosum group F proteinXPBC-ERCC-3 proteinXPC protein, humanX-ray Repair Cross Complementing Protein 1XRCC1 protein, human

Identifiers

PMID26681190
PMCPMC4683048
OpenAlexW2297818496

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