ArticlePloS one2015
Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The Circadian Composition of Breast Milk: A Natural Starting Point for Chrononutrition.Current nutrition reports · 2026Review
- Feeding Expressed Breast Milk Alters the Microbial Network of Breast Milk and Increases Breast Milk Microbiome Diversity over Time.Microorganisms · 2024Article
- Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk.Endocrine reviews · 2024Review
- Article
- Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring.Nutrients · 2023Article
- Leptin as a key regulator of the adipose organ.Reviews in endocrine & metabolic disorders · 2022Review
- Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.Chemosphere · 2022Article
- DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.Nutrients · 2021Article
- Adiponectin and the regulation of gastric content volume in the newborn rat.World journal of gastroenterology · 2021Article
- Rat Milk and Plasma Immunological Profile throughout Lactation.Nutrients · 2021Article
- Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2021Article
- Article
- Innovations in Infant Feeding: Future Challenges and Opportunities in Obesity and Cardiometabolic Disease.Nutrients · 2020Review
- Sexually Dimorphic Associations between Maternal Factors and Human Milk Hormonal Concentrations.Nutrients · 2020Article
- Feto-Maternal Crosstalk in the Development of the Circadian Clock System.Frontiers in neuroscience · 2020Review
- Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons.Physiology & behavior · 2019Article
- Human milk as "chrononutrition": implications for child health and development.Pediatric research · 2019Review
- Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations.Obesity (Silver Spring, Md.) · 2019Article
- Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A significant number of chronic diseases are linked to perinatal nutrition, and prevention may be associated to naturally occurring components of breast milk. One key hormone in breast milk is leptin, related with the protection from obesity in the adulthood, thus knowing its changes through the day or lactation is crucial. We aimed to investigate the daily rhythms in the milk levels of leptin, together with other two related hormones, ghrelin and adiponectin, during lactation (days 5, 10 and 15) in rat dams, and the relation with morphometric parameters (dams and pups). Summarizing the main results, the existence of biological rhythms, but not daily and maybe circasemidian, was confirmed for the three hormones at the earliest period of lactation. The correlations performed generally showed a possible dependence of milk hormone levels on plasma levels at the early phase of lactation, while with the progression of lactation this dependence may fade and the hormone levels are suggested to be more dependent on mammary gland production/maturation. There was also a correlation between milk leptin and adiponectin levels, especially in the first half of lactation, suggesting a possible parallel regulation. Interestingly, we describe a milk leptin surge around the mid of lactation (at day 10) which may be related with pup's growth (males and females) and with the well-known (in the literature) plasma leptin surge in pups. All this knowledge may be crucial for future applications in the development of formula milk and in relation with the role of leptin surge during lactation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.