Evidence map›Paper›PMID 26680603›Full record

Trial reportCancer epidemiology2016

Evaluation of breast cancer risk associated with tea consumption by menopausal and estrogen receptor status among Chinese women in Hong Kong.

Mengjie Li, Lap Ah Tse, Wing-Cheong Chan, Chi-hei Kwok, Siu-lan Leung, Cherry Wu, Wai-cho Yu, Ignatius Tak-sun Yu, Chloe Hui-Tung Yu, Feng Wang and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01885039 (Characterization of Molecular Subtypes of Breast Cancer and Their Relationships With Known Breast Cancer Risk Factors Among Chinese Women in Hong Kong - A Pilot Study), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01885039 completednot on this map

Characterization of Molecular Subtypes of Breast Cancer and Their Relationships With Known Breast Cancer Risk Factors Among Chinese Women in Hong Kong - A Pilot Study

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2013 to 2019Enrolled400ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Green tea (Camellia sinensis) for the prevention of cancer.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Anticarcinogenic potentials of tea catechins.Frontiers in nutrition · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Phytochemical Study on Antioxidant and Antiproliferative Activities of MoroccanEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Mengjie LiJC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lap Ah TseJC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: shelly@cuhk.edu.hk.
Wing-Cheong ChanDepartment of Surgery, North District Hospital, Hong Kong SAR, China.
Chi-hei KwokDepartment of Oncology, Princess Margaret Hospital, Hong Kong SAR, China.
Siu-lan LeungDepartment of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
Cherry WuDepartment of Pathology, North District Hospital, Hong Kong SAR, China.
Wai-cho YuDepartment of Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
Ignatius Tak-sun YuJC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chloe Hui-Tung YuLi Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Feng WangJC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hyuna SungGenetic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Xiaohong R YangGenetic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Chinese University of Hong Kong · HKNational Institutes of Health · USPamela Youde Nethersole Eastern Hospital · CNUniversity of Hong Kong · HK

Funding

Genetic EpidemiologyZIACP005803 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GOLDSTEIN, ALISA · 2009 to 2025
$24.8M
CLINICAL/IMMUNOLOGIC/GENETIC ANALYSES OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROMEZ01AI000732 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RAO, VEMULKONDA · 1995 to 2008
$1.1M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

purposeExperimental studies implicate tea and tea polyphenols may be preventive against breast cancer, but evidence from epidemiological studies has been inconsistent. We conducted a hospital-based case-control study to evaluate the role of tea especially green tea in breast cancer etiology.

methodsWe consecutively recruited 756 incident breast cancer cases and 789 hospital controls who had completed information on tea consumption. We calculated odds ratios (ORs) for tea consumption using unconditional multivariable logistic regression. We further conducted stratified analyses to assess whether the effect of tea consumption varied by menopausal status and estrogen receptor (ER).

resultsOverall, 439 (58.1%) breast cancer cases and 434 (55.0%) controls reported habits of regular tea drinking, showing an adjusted OR of 1.01 (95%CI: 0.78-1.31) and 1.20 (95%CI: 0.80-1.78) for any tea and green tea drinking, respectively. Regular tea drinking was significantly associated with a lower risk for breast cancer in pre-menopausal women (OR=0.62, 95%CI: 0.40-0.97) but an increased risk in post-menopausal women (OR=1.40, 95%CI: 1.00-1.96). The positive association among postmenopausal women was strongest among ER-negative green tea drinkers (OR=2.99, 95% CI: 1.26-7.11).

conclusionsTea or green tea drinking was not associated with overall breast cancer risk, which may be masked by the differential effect in pre- and post-menopausal women.

Indexed as

TeaAdultAgedAged, 80 and overAsian PeopleBreast NeoplasmsCase-Control StudiesFemaleHong KongHumansMenopauseMiddle AgedOdds RatioPrognosisReceptors, EstrogenRisk FactorsReceptors, EstrogenTeaBreast cancerEstrogen receptor statusMenopausal statusTea consumption

Identifiers

PMID26680603
PMCPMC6719777
OpenAlexW2190348631

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.