ArticleNature communications2015
Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 103 citations in OpenAlex.
- Exploring the biochemical and biological functions of copper radical oxidases in the vascular wilt phytopathogenApplied and environmental microbiology · 2026Article
- Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase.The Biochemical journal · 2026Article
- Molecular Insights into the Activation of a Fungal Copper Radical Oxidase by Peroxidases.Chem & bio engineering · 2026Article
- Galactose Oxidase and Horseradish Peroxidase Hybrid Nanoflowers for Biosynthesis of 1-Tetralone.Applied biochemistry and biotechnology · 2025Article
- Expansion of Auxiliary Activity Family 5 sequence space via biochemical characterization of six new copper radical oxidases.Applied and environmental microbiology · 2024Article
- Homo- and Heterogeneous Benzyl Alcohol Catalytic Oxidation Promoted by Mononuclear Copper(II) Complexes: The Influence of the Ligand upon Product Conversion.Molecules (Basel, Switzerland) · 2024Article
- Genome evolution and transcriptome plasticity is associated with adaptation to monocot and dicot plants in Colletotrichum fungi.GigaScience · 2024Article
- Effective biosynthesis of 2,5-furandicarboxylic acid from 5-hydroxymethylfurfural via a bi-enzymatic cascade system using bacterial laccase and fungal alcohol oxidase.Biotechnology for biofuels and bioproducts · 2023Article
- Enzymatic reactions towards aldehydes: An overview.Flavour and fragrance journal · 2023Review
- Expanding the Physiological Role of Aryl-Alcohol Flavooxidases as Quinone Reductases.Applied and environmental microbiology · 2023Article
- Tandem metalloenzymes gate plant cell entry by pathogenic fungi.Science advances · 2022Article
- A simple and direct ionic chromatography method to monitor galactose oxidase activity.RSC advances · 2022Article
- Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications.Engineering microbiology · 2022Review
- Active-Site Engineering Switches Carbohydrate Regiospecificity in a Fungal Copper Radical Oxidase.ACS catalysis · 2022Article
- α-Dioxygenases (α-DOXs): Promising Biocatalysts for the Environmentally Friendly Production of Aroma Compounds.Chembiochem : a European journal of chemical biology · 2022Review
- Tunable Production of (ACS catalysis · 2022Article
- Basidiomycota Fungi and ROS: Genomic Perspective on Key Enzymes Involved in Generation and Mitigation of Reactive Oxygen Species.Frontiers in fungal biology · 2022Review
- A survey of substrate specificity among Auxiliary Activity Family 5 copper radical oxidases.Cellular and molecular life sciences : CMLS · 2021Article
- Identification of Copper-Containing Oxidoreductases in the Secretomes of ThreeApplied and environmental microbiology · 2021Article
- A LignocellulolyticJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
Alcohol oxidases, including carbohydrate oxidases, have a long history of research that has generated fundamental biological understanding and biotechnological applications. Despite a long history of study, the galactose 6-oxidase/glyoxal oxidase family of mononuclear copper-radical oxidases, Auxiliary Activity Family 5 (AA5), is currently represented by only very few characterized members. Here we report the recombinant production and detailed structure-function analyses of two homologues from the phytopathogenic fungi Colletotrichum graminicola and C. gloeosporioides, CgrAlcOx and CglAlcOx, respectively, to explore the wider biocatalytic potential in AA5. EPR spectroscopy and crystallographic analysis confirm a common active-site structure vis-à-vis the archetypal galactose 6-oxidase from Fusarium graminearum. Strikingly, however, CgrAlcOx and CglAlcOx are essentially incapable of oxidizing galactose and galactosides, but instead efficiently catalyse the oxidation of diverse aliphatic alcohols. The results highlight the significant potential of prospecting the evolutionary diversity of AA5 to reveal novel enzyme specificities, thereby informing both biology and applications.
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