ArticleGenes & development2015
Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.
Article in Genes & development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Gene expression programs underlying spinal commissural neuron differentiation and axon growth across the midline.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Midline assembloids reveal regulators of human axon guidance.Science (New York, N.Y.) · 2025Article
- Regulation of axon pathfinding by astroglia across genetic model organisms.Frontiers in cellular neuroscience · 2023Review
- Intracellular Trafficking Mechanisms that Regulate Repulsive Axon Guidance.Neuroscience · 2023Review
- Cbln1 regulates axon growth and guidance in multiple neural regions.PLoS biology · 2022Article
- Neuropilin 2/Plexin-A3 Receptors Regulate the Functional Connectivity and the Excitability in the Layers 4 and 5 of the Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Dorsal commissural axon guidance in the developing spinal cord.Current topics in developmental biology · 2021Review
- Molecular mechanisms regulating axon responsiveness at the midline.Developmental biology · 2020Article
- Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.Nature reviews. Neuroscience · 2019Review
- Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation.Scientific reports · 2018Article
- Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.PLoS genetics · 2018Article
- Article
- PLXNA1 developmental encephalopathy with syndromic features: A case report and review of the literature.American journal of medical genetics. Part A · 2017Article
- Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins.Cell reports · 2017Article
- Commissural axon navigation: Control of midline crossing in the vertebrate spinal cord by the semaphorin 3B signaling.Cell adhesion & migration · 2016Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Commissural axon guidance depends on a myriad of cues expressed by intermediate targets. Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossing commissural axons to mediate floor plate repulsion in the mouse spinal cord. Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissural axons prior to midline crossing and can mediate precrossing semaphorin-induced repulsion in vitro. How premature semaphorin-induced repulsion of precrossing axons is suppressed in vivo is not known. We discovered that a novel source of floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfinding. Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precrossing axons in the ventral spinal cord, which can be rescued by inhibiting plexin-A1 signaling in vivo. Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning as a molecular sink to sequester semaphorins, preventing premature repulsion of precrossing axons prior to subsequent down-regulation, and allowing for semaphorin-mediated repulsion of post-crossing axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.