ArticleJournal of chromatography. A2015
The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography.
Article in Journal of chromatography. A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Integrated counter current separation and omics approaches for discovery of bioactive compounds from medicinal plants.Frontiers in pharmacology · 2026Review
- Tandem of Countercurrent Separation and qHNMR Enables Gravimetric Analyses: Absolute Quantitation of theAnalytical chemistry · 2021Article
- Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography.Molecules (Basel, Switzerland) · 2020Review
- Additive Analytics: Easy Transformation of Low-Cost Fused Deposition Modeling Three-Dimensional Printers for HPTLC Sample Application.ACS omega · 2020Article
- Evidence for Chemopreventive and Resilience Activity of Licorice:Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo.Journal of chromatography. A · 2018Article
- Article
- Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.Journal of chromatography. A · 2017Article
- A regioselective etherification of pyridoxineTetrahedron letters · 2017Article
- Countercurrent assisted quantitative recovery of metabolites from plant-associated natural deep eutectic solvents.Fitoterapia · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The TLC-based Generally Useful Estimate of Solvent Systems (GUESS) method was employed for countercurrent chromatography solvent system selection, in order to separate the three synthetic isomers: 3-O-methylpyridoxine, 4'-O-methylpyridoxine (ginkgotoxin), and 5'-O-methylpyridoxine. The Rf values of the three isomers indicated that ChMWat+2 (chloroform-methanol-water 10:5:5, v/v/v) was appropriate for the countercurrent separation. The isomer separation was highly selective and demonstrated that the TLC-based GUESS method can accelerate solvent system selection for countercurrent separation. Accordingly, the study re-emphasizes the practicality of TLC as a tool to facilitate the rapid development of new countercurrent and centrifugal partition chromatography methods for this solvent system. Purity and structure characterization of all samples was performed by quantitative (1)H NMR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.