ArticleScience (New York, N.Y.)2015
An essential cell cycle regulation gene causes hybrid inviability in Drosophila.
Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Article
- Genomic Signatures of Speciation in Butterflies.Systematic biology · 2026Article
- A newborn F-box gene blocks gene flow by selectively degrading phosphoglucomutase in species hybrids.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- A new hybrid incompatibility locus between Drosophila melanogaster and Drosophila sechellia.Genetics · 2024Article
- Article
- Preparation of Xenopus borealis and Xenopus tropicalis Egg Extracts for Comparative Cell Biology and Evolutionary Studies.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Hybrid breakdown in male reproduction between recently diverged Drosophila melanogaster populations has a complex and variable genetic architecture.Evolution; international journal of organic evolution · 2023Article
- Article
- Hybrid incompatibility between Drosophila virilis and D. lummei is stronger in the presence of transposable elements.Journal of evolutionary biology · 2022Article
- Testing the Drosophila maternal haploid gene for functional divergence and a role in hybrid incompatibility.G3 (Bethesda, Md.) · 2022Article
- Divergence of X-linked trans regulatory proteins and the misexpression of gene targets in sterile Drosophila pseudoobscura hybrids.BMC genomics · 2022Article
- Genetic architecture and temporal analysis of Caenorhabditis briggsae hybrid developmental delay.PloS one · 2022Article
- Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila.Molecular biology and evolution · 2021Article
- The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.PLoS genetics · 2021Article
- Comparative studies on speciation: 30 years since Coyne and Orr.Evolution; international journal of organic evolution · 2021Article
- Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From theFrontiers in genetics · 2021Review
- Protein Complexes Form a Basis for Complex Hybrid Incompatibility.Frontiers in genetics · 2021Review
- A single pleiotropic locus influences the rate of hybridization between two sibling species ofEcology and evolution · 2020Article
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Authors and funding
9 authors.
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Abstract
Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems.
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