ArticleJournal of biomechanics2016
A clinical method for mapping and quantifying blood stasis in the left ventricle.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Observational Study to Assess the Efficacy of New Quantitative Imaging Methods to Assess the Risk of Acute and Subacute Thromboembolic Complications of Myocardial Infarction
Quantification of Intraventricular Stasis and Thromboembolic Risk With New Imaging Methods in Patients With Non Ischemic Dilated Myocardiopathy
Personalizing The Risk Of Stroke And Silent Brain Infarct In Cardiovascular Disease
Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Beyond CHAAnnals of biomedical engineering · 2026Article
- Left atrial flow and thrombosis risk from 4D CT contrast dynamics by physics-informed neural network and indicator dilution theory.bioRxiv : the preprint server for biology · 2026Article
- Flow transport and not ejection fraction determines blood stasis in patients with impaired left ventricular systolic function.Physiological reports · 2025Article
- Left ventricular flow dynamics by cardiac imaging techniques in heart failure patients: state of the art.Cardiovascular ultrasound · 2025Review
- Super-resolution left ventricular flow and pressure mapping by Navier-Stokes-informed neural networks.Computers in biology and medicine · 2025Article
- Article
- Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2024Article
- Super-resolution Left Ventricular Flow and Pressure Mapping by Navier-Stokes-Informed Neural Networks.bioRxiv : the preprint server for biology · 2024Article
- Effect of Sinotubular Junction Size on TAVR Leaflet Thrombosis: A Fluid-Structure Interaction Analysis.Annals of biomedical engineering · 2024Article
- Left Ventricular Assist Device Pump Obstruction Reduces Native Heart Efficiency.Bioengineering (Basel, Switzerland) · 2023Article
- Efficient multi-fidelity computation of blood coagulation under flow.PLoS computational biology · 2023Article
- Pulmonary vein flow split effects in patient-specific simulations of left atrial flow.Computers in biology and medicine · 2023Article
- Increased Blood Residence Time as Markers of High-Risk Patent Foramen Ovale.Translational stroke research · 2023Article
- Assessment of Blood Flow Transport in the Left Ventricle Using Ultrasound. Validation Against 4-D Flow Cardiac Magnetic Resonance.Ultrasound in medicine & biology · 2022Article
- Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.PLoS computational biology · 2022Article
- Non-Newtonian blood rheology impacts left atrial stasis in patient-specific simulations.International journal for numerical methods in biomedical engineering · 2022Article
- Demonstration of Patient-Specific Simulations to Assess Left Atrial Appendage Thrombogenesis Risk.Frontiers in physiology · 2021Article
- Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation.Royal Society open science · 2020Article
- Ventricular Flow Field Visualization During Mechanical Circulatory Support in the Assisted Isolated Beating Heart.Annals of biomedical engineering · 2020Article
- Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
In patients at risk of intraventrcular thrombosis, the benefits of chronic anticoagulation therapy need to be balanced with the pro-hemorrhagic effects of therapy. Blood stasis in the cardiac chambers is a recognized risk factor for intracardiac thrombosis and potential cardiogenic embolic events. In this work, we present a novel flow image-based method to assess the location and extent of intraventricular stasis regions inside the left ventricle (LV) by digital processing flow-velocity images obtained either by phase-contrast magnetic resonance (PCMR) or 2D color-Doppler velocimetry (echo-CDV). This approach is based on quantifying the distribution of the blood Residence Time (TR) from time-resolved blood velocity fields in the LV. We tested the new method in illustrative examples of normal hearts, patients with dilated cardiomyopathy and one patient before and after the implantation of a left ventricular assist device (LVAD). The method allowed us to assess in-vivo the location and extent of the stasis regions in the LV. Original metrics were developed to integrate flow properties into simple scalars suitable for a robust and personalized assessment of the risk of thrombosis. From a clinical perspective, this work introduces the new paradigm that quantitative flow dynamics can provide the basis to obtain subclinical markers of intraventricular thrombosis risk. The early prediction of LV blood stasis may result in decrease strokes by appropriate use of anticoagulant therapy for the purpose of primary and secondary prevention. It may also have a significant impact on LVAD device design and operation set-up.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.