ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of Chin-down-plus-larynx-tightening maneuver on swallowing function after minimally invasive esophagectomy: A randomized controlled trail.Cancer medicine · 2020Trial
- Muscle function and electromyography: (almost) 70 years since Doty and Bosma (1956).Journal of neurophysiology · 2025Article
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- The effect of stiffness and hole size on nipple compression in infant suckling.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Oropharyngeal capsaicin exposure improves infant feeding performance in an animal model of superior laryngeal nerve damage.Journal of neurophysiology · 2022Article
- Acute effects of radiation treatment to submental muscles on burrowing and swallowing behaviors in a rat model.PloS one · 2022Article
- Swallowing dysfunction following radiation to the rat mylohyoid muscle is associated with sensory neuron injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.Dysphagia · 2021Article
- Does birth weight affect neonatal body weight, growth, and physiology in an animal model?PloS one · 2021Article
- Article
- Effects of Superior Laryngeal Nerve Lesion on Kinematics of Swallowing and Airway Protection in an Infant Pig Model.Dysphagia · 2020Article
- Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.Journal of neurophysiology · 2020Article
- The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.Journal of biomechanics · 2020Article
- Reduced Coordination of Hyolaryngeal Elevation and Bolus Movement in a Pig Model of Preterm Infant Swallowing.Dysphagia · 2020Article
- Respiratory-Swallow Pattern Following Total Laryngectomy.Dysphagia · 2020Article
- Recurrent laryngeal nerve transection in mice results in translational upper airway dysfunction.The Journal of comparative neurology · 2020Article
- Preterm Birth Impacts the Timing and Excursion of Oropharyngeal Structures during Infant Feeding.Integrative organismal biology (Oxford, England) · 2020Article
- Chin-down-plus-larynx-tightening maneuver improves choking cough after esophageal cancer surgery.Annals of translational medicine · 2019Article
- Preterm birth disrupts the development of feeding and breathing coordination.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Specific Vagus Nerve Lesion Have Distinctive Physiologic Mechanisms of Dysphagia.Frontiers in neurology · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system is poorly understood. Recurrent laryngeal nerve lesion (RLN) results in increased aspiration, though the mechanism for this is unclear. This study aimed to determine the effect of unilateral RLN lesion on the motor coordination of infant liquid feeding. We hypothesized that 1) RLN lesion results in modified swallow kinematics, 2) postlesion oropharyngeal kinematics of unsafe swallows differ from those of safe swallows, and 3) nonswallowing phases of the feeding cycle show changed kinematics postlesion. We implanted radio opaque markers in infant pigs and filmed them pre- and postlesion with high-speed videofluoroscopy. Markers locations were digitized, and swallows were assessed for airway protection. RLN lesion resulted in modified kinematics of the tongue relative to the epiglottis in safe swallows. In lesioned animals, safe swallow kinematics differed from unsafe swallows. Unsafe swallow postlesion kinematics resembled prelesion safe swallows. The movement of the tongue was reduced in oral transport postlesion. Between different regions of the tongue, response to lesion was similar, and relative timing within the tongue was unchanged. RLN lesion has a pervasive effect on infant feeding kinematics, related to the efficiency of airway protection. The timing of tongue and hyolaryngeal kinematics in swallows is a crucial locus for swallow disruption. Laryngeal sensation is essential for the central coordination in feeding of oropharyngeal structures receiving motor inputs from different cranial nerves.
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