ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Influence of muscle metabolic heterogeneity in determining the V̇o2p kinetic response to ramp-incremental exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Lessons from history forFrontiers in physiology · 2025Review
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- Increases in the incremental exercise mean response time across the steady state domain: Implications for exercise testing & prescription.Sports medicine and health science · 2024Article
- Impaired pulmonary and muscle function during moderate exercise in female patients recovered from SARS-CoV-2.Scientific reports · 2022Article
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- Identification of Non-Invasive Exercise Thresholds: Methods, Strategies, and an Online App.Sports medicine (Auckland, N.Z.) · 2022Review
- Impact of supine versus upright exercise on muscle deoxygenation heterogeneity during ramp incremental cycling is site specific.European journal of applied physiology · 2021Article
- An Examination and Critique of Current Methods to Determine Exercise Intensity.Sports medicine (Auckland, N.Z.) · 2020Review
- Photobiomodulation 30 min or 6 h Prior to Cycling Does Not Alter Resting Blood Flow Velocity, Exercise-Induced Physiological Responses or Time to Exhaustion in Healthy Men.Frontiers in physiology · 2020Article
- Interlimb differences in parameters of aerobic function and local profiles of deoxygenation during double-leg and counterweighted single-leg cycling.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Establishing the V̇oJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Mechanisms underlying extremely fast muscle V˙OPhysiological reports · 2018Article
- Regulation of oxidative phosphorylation is different in electrically- and cortically-stimulated skeletal muscle.PloS one · 2018Article
- The effects of short work vs. longer work periods within intermittent exercise on V̇oJournal of applied physiology (Bethesda, Md. : 1985) · 2017Article
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6 authors.
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Abstract
The pulmonary O2 uptake (V̇o2p) response to ramp-incremental (RI) exercise increases linearly with work rate (WR) after an early exponential phase, implying that a single time constant (τ) and gain (G) describe the response. However, variability in τ and G of V̇o2p kinetics to different step increments in WR is documented. We hypothesized that the "linear" V̇o2p-WR relationship during RI exercise results from the conflation between WR-dependent changes in τ and G. Nine men performed three or four repeats of RI exercise (30 W/min) and two step-incremental protocols consisting of four 60-W increments beginning from 20 W or 50 W. During testing, breath-by-breath V̇o2p was measured by mass spectrometry and volume turbine. For each individual, the V̇o2p RI response was characterized with exponential functions containing either constant or variable τ and G values. A relationship between τ and G vs. WR was determined from the step-incremental protocols to derive the variable model parameters. τ and G increased from 21 ± 5 to 98 ± 20 s and from 8.7 ± 0.6 to 12.0 ± 1.9 ml·min(-1)·W(-1) for WRs of 20-230 W, respectively, and were best described by a second-order (τ) and a first-order (G) polynomial function of WR (lowest Akaike information criterion score). The sum of squared residuals was not different (P > 0.05) when the V̇o2p RI response was characterized with either the constant or variable models, indicating that they described the response equally well. Results suggest that τ and G increase progressively with WR during RI exercise. Importantly, these relationships may conflate to produce a linear V̇o2p-WR response, emphasizing the influence of metabolic heterogeneity in determining the apparent V̇o2p-WR relationship during RI exercise.
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