Evidence map›Paper›PMID 26679553›Full record

ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2016

Primary Ewing Family of Tumors of the Jaw Has a Better Prognosis Compared to Tumors of Extragnathic Sites.

Adepitan A Owosho, Eugene Ko, Haley I Rosenberg, SaeHee K Yom, Cristina R Antonescu, Joseph M Huryn, Cherry L Estilo

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Ewing's Sarcoma of Mandible: A Case Report with Review of Literature.International journal of clinical pediatric dentistry · 2024
    Article
  3. Primary EwingJournal of maxillofacial and oral surgery · 2023
    Article
  4. PAX7 expression in sarcomas bearing the EWSR1-NFATC2 translocation.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adepitan A OwoshoDental Oncology Research Fellow, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Eugene KoFormer Research Fellow, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY; Clinical Assistant Professor, School of Dentistry, University of Michigan, Ann Arbor, MI.
Haley I RosenbergResearch Study Assistant, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
SaeHee K YomAssistant Attending, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Cristina R AntonescuAttending, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Joseph M HurynChief, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Cherry L EstiloAttending, Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: estiloc@mskcc.org.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposePrimary Ewing sarcoma of the jaw is rare. The aim of this study was to describe new cases of primary Ewing sarcoma of the jaw and investigate reported prognostic factors of Ewing sarcoma in this series and treatment outcome. MATERIALS AND

methodsSix patients with primary Ewing sarcoma of the jaw were treated at the Memorial Sloan Kettering Cancer Center (MSKCC) from 1992 through 2013. Clinical data, pathology reports, treatment prescribed, treatment regimens, outcome, and follow-up information were reviewed.

resultsFive of 6 patients were female and 5 cases were in the mandible. No patient presented with metastatic disease at diagnosis. All cases were positive for CD99, and 3 patients with genetic confirmation were positive for EWS-FLI1 fusion or EWSR1 gene rearrangement. All patients received induction multiagent chemotherapy and surgical resection and 2 patients received adjuvant radiotherapy. Total (grade IV) or nearly total (grade III) tumor necrosis in 3 of 5 patients (60%) assessed for histologic response to chemotherapy indicated intense sensitivity. All patients were alive and free of disease, with no history of local recurrence, at a median follow-up period of 6.5 years.

conclusionPatients with primary Ewing sarcoma of the jaw have a good prognosis and metastasis is an uncommon occurrence at initial presentation.

Indexed as

AdolescentBone NeoplasmsChildChild, PreschoolFemaleHumansJaw NeoplasmsMalePrognosisRetrospective StudiesSarcoma, EwingSurvival AnalysisTomography, X-Ray ComputedTreatment OutcomeYoung Adult

Identifiers

PMID26679553
PMCPMC4850111
OpenAlexW2115075486

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.