ArticleScientific reports2015
BODIPY-Based Fluorescent Probes for Sensing Protein Surface-Hydrophobicity.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 98 citations in OpenAlex.
- Water-Soluble Ammonium BODIPYs: Synthesis, Photophysics, Photogelation, and Antimicrobial Activity.Chemistry, an Asian journal · 2026Article
- Novel "C-Clamp" Design of Highly Selective Small-Molecule Sensors for Kinase Proteins.Chemical & biomedical imaging · 2026Article
- Pyridinium- and bromine-substituted distyryl-BODIPY dyes for mitochondria-targeted photodynamic therapy.Scientific reports · 2026Article
- Encapsulation of a Highly Acid-Stable Dicyano-Bodipy in Zr-Based Metal-Organic Frameworks with Increased Fluorescence Lifetime and Quantum Yield Within the Solid Solution Concept.Molecules (Basel, Switzerland) · 2025Article
- Tuning Conductance in BODIPY-Based Single-Molecule Junctions.Nano letters · 2025Article
- Pitfalls of Using ANS Dye Under Molecular Crowding Conditions.International journal of molecular sciences · 2024Article
- Computational investigation of the effect of BODIPY labelling on peptide-membrane interaction.Scientific reports · 2024Article
- Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants.ACS central science · 2024Article
- Ultrafast fluorescence depolarisation in green fluorescence protein tandem dimers as hydrophobic environment sensitive probes.Physical chemistry chemical physics : PCCP · 2023Article
- Surfactant Micellar and Vesicle Microenvironments and Structures under Synthetic Organic Conditions.Journal of the American Chemical Society · 2023Article
- Turning Food Protein Waste into Sustainable Technologies.Chemical reviews · 2023Review
- Near-Infrared Probes for Biothiols (Cysteine, Homocysteine, and Glutathione): A Comprehensive Review.ACS omega · 2023Review
- Nonbenzenoid BODIPY Analogues: Synthesis, Structural Organization, Photophysical Studies, and Cell Internalization of BiocompatibleACS omega · 2022Article
- Application ofMolecules (Basel, Switzerland) · 2022Article
- A selective hybrid fluorescent sensor for fructose detection based on a phenylboronic acid and BODIPY-based hydrophobicity probe.RSC advances · 2022Article
- BODIPY nanoparticles functionalized with lactose for cancer-targeted and fluorescence imaging-guided photodynamic therapy.Scientific reports · 2022Article
- Cytotoxicity of Amino-BODIPY Modulated via Conjugation with 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones.ChemistryOpen · 2021Article
- Dominant entropic binding of perfluoroalkyl substances (PFASs) to albumin protein revealed byChemosphere · 2021Article
- Resolving Binding Events on the Multifunctional Human Serum Albumin.ChemMedChem · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mapping surface hydrophobic interactions in proteins is key to understanding molecular recognition, biological functions, and is central to many protein misfolding diseases. Herein, we report synthesis and application of new BODIPY-based hydrophobic sensors (HPsensors) that are stable and highly fluorescent for pH values ranging from 7.0 to 9.0. Surface hydrophobic measurements of proteins (BSA, apomyoglobin, and myoglobin) by these HPsensors display much stronger signal compared to 8-anilino-1-naphthalene sulfonic acid (ANS), a commonly used hydrophobic probe; HPsensors show a 10- to 60-fold increase in signal strength for the BSA protein with affinity in the nanomolar range. This suggests that these HPsensors can be used as a sensitive indicator of protein surface hydrophobicity. A first principle approach is used to identify the molecular level mechanism for the substantial increase in the fluorescence signal strength. Our results show that conformational change and increased molecular rigidity of the dye due to its hydrophobic interaction with protein lead to fluorescence enhancement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.