ArticleAnnals of medicine2016
Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.
Article in Annals of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Relationships between circadian measures, depression, and response to antidepressant treatment: A preliminary investigation.Psychiatry research · 2017Trial
- Fluoxetine attenuates UPR-activation, neuroinflammation, and oxidative stress in a nitroglycerin-induced rat model of migraine.Iranian journal of basic medical sciences · 2026Article
- Machine Learning Models to Identify Clinically Significant Anxiety in Short-Term Insomnia Using Accelerometers.Depression and anxiety · 2025Article
- Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm".Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- A new model for the treatment of type 2 diabetes mellitus based on rhythm regulations under the framework of psychosomatic medicine: a real-world study.Scientific reports · 2023Article
- Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression.Pharmaceutics · 2021Review
- Every Night and Every Morn: Effect of Variation inFrontiers in psychiatry · 2021Article
- Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress.Frontiers in psychiatry · 2019Review
- Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats.Journal of circadian rhythms · 2018Article
- Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice.Scientific reports · 2018Article
- Nitrous oxide (NTrials · 2017Article
- Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging.Frontiers in neurology · 2017Review
- Disrupted Ultradian Activity Rhythms and Differential Expression of Several Clock Genes in Interleukin-6-Deficient Mice.Frontiers in neurology · 2017Article
- Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior.PloS one · 2017Article
- Altered Expression Pattern of Clock Genes in a Rat Model of Depression.The international journal of neuropsychopharmacology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionDisturbances of circadian rhythms are a key symptom of mood and anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) - commonly used antidepressant drugs - also modulate aspects of circadian rhythmicity. However, their potential to restore circadian disturbances in depression remains to be investigated. MATERIALS AND
methodsThe effects of the SSRI fluoxetine on genetically based, depression-related circadian disruptions at the behavioral and molecular level were examined using mice selectively bred for high anxiety-related and co-segregating depression-like behavior (HAB) and normal anxiety/depression behavior mice (NAB).
resultsThe length of the circadian period was increased in fluoxetine-treated HAB as compared to NAB mice while the number of activity bouts and light-induced entrainment were comparable. No difference in hippocampal Cry2 expression, previously reported to be dysbalanced in untreated HAB mice, was observed, while Per2 and Per3 mRNA levels were higher in HAB mice under fluoxetine treatment. DISCUSSION: The present findings provide evidence that fluoxetine treatment normalizes disrupted circadian locomotor activity and clock gene expression in a genetic mouse model of high trait anxiety and depression. An interaction between the molecular mechanisms mediating the antidepressant response to fluoxetine and the endogenous regulation of circadian rhythms in genetically based mood and anxiety disorders is proposed.
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