ArticleEuropean radiology2016
AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.Cardiovascular research · 2024Article
- Relationships between Osteopontin, Osteoprotegerin, and Other Extracellular Matrix Proteins in Calcifying Arteries.Biomedicines · 2024Article
- Early Development of Atherosclerotic Plaques in the Coronary Arteries after Radiotherapy for Breast Cancer (BACCARAT Study).Journal of cardiovascular development and disease · 2023Article
- Blind spectral unmixing for characterization of plaque composition based on multispectral photoacoustic imaging.Scientific reports · 2023Article
- Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study.Antioxidants (Basel, Switzerland) · 2023Article
- Adventitial adaptive immune cells are associated with ascending aortic dilatation in patients with a bicuspid aortic valve.Frontiers in cardiovascular medicine · 2023Article
- RNA Sequencing Reveals the Differentially Expressed circRNAs between Stable and Unstable Carotid Atherosclerotic Plaques.Genetics research · 2023Article
- The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies.International journal of molecular sciences · 2022Review
- Prognostic Value of Serial Coronary CT Angiography in Atherosclerotic Plaque Modification: What have we learnt?Current cardiovascular imaging reports · 2022Article
- Altered Peroxisome Proliferator-Activated Receptor Alpha Signaling in Variably Diseased Peripheral Arterial Segments.Frontiers in cardiovascular medicine · 2022Article
- Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT-A comparison with histology.PloS one · 2022Article
- Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement.AJNR. American journal of neuroradiology · 2021Article
- Review
- Next-Generation Hardware Advances in CT: Cardiac Applications.Radiology · 2021Review
- Extraction of Coronary Atherosclerotic Plaques From Computed Tomography Imaging: A Review of Recent Methods.Frontiers in cardiovascular medicine · 2021Review
- Advances in CT Techniques in Vascular Calcification.Frontiers in cardiovascular medicine · 2021Review
- Diabetic vasculopathy: macro and microvascular injury.Current pathobiology reports · 2020Article
- Vascular branching geometry relating to portal hypertension: a study of liver microvasculature in cirrhotic rats by X-ray phase-contrast computed tomography.Quantitative imaging in medicine and surgery · 2020Article
- A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.Mediators of inflammation · 2020Article
- Cellular-resolution 3D virtual histology of human coronary arteries using x-ray phase tomography.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
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Abstract
objectivesTo evaluate the potential of grating-based phase-contrast computed-tomography (gb-PCCT) to classify human carotid and coronary atherosclerotic plaques according to modified American Heart Association (AHA) criteria.
methodsExperiments were carried out at a laboratory-based set-up consisting of X-ray tube (40 kVp), grating-interferometer and detector. Eighteen human carotid and coronary artery specimens were examined. Histopathology served as the standard of reference. Vessel cross-sections were classified as AHA lesion type I/II, III, IV/V, VI, VII or VIII plaques by two independent reviewers blinded to histopathology. Conservative measurements of diagnostic accuracies for the detection and differentiation of plaque types were evaluated.
resultsA total of 127 corresponding gb-PCCT/histopathology sections were analyzed. Based on histopathology, lesion type I/II was present in 12 (9.5 %), III in 18 (14.2 %), IV/V in 38 (29.9 %), VI in 16 (12.6 %), VII in 34 (26.8 %) and VIII in 9 (7.0 %) cross-sections. Sensitivity, specificity and positive and negative predictive value were ≥0.88 for most analyzed plaque types with a good level of agreement (Cohen's kappa = 0.90). Overall, results were better in carotid (kappa = 0.97) than in coronary arteries (kappa = 0.85). Inter-observer agreement was high with kappa = 0.85, p < 0.0001.
conclusionsThese results indicate that gb-PCCT can reliably classify atherosclerotic plaques according to modified AHA criteria with excellent agreement to histopathology. KEY POINTS: • Different atherosclerotic plaque types display distinct morphological features in phase-contrast CT. • Phase-contrast CT can detect and differentiate AHA plaque types. • Calcifications caused streak artefacts and reduced sensitivity in type VI lesions. • Overall agreement was higher in carotid than in coronary arteries.
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