ArticlePediatric research2016
Human milk glycosaminoglycans inhibit in vitro the adhesion of Escherichia coli and Salmonella fyris to human intestinal cells.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Limited support for a direct connection between prebiotics and intestinal permeability - a systematic review.Glycoconjugate journal · 2024Pooled it
- Metabolic fate of milk glycosaminoglycans in breastfed and formula fed newborns.Glycoconjugate journal · 2016Trial
- Clinical characteristics and risk factor analysis of invasive non-typhoidal Salmonella infection in children.Gut pathogens · 2026Article
- Sialyllactose Attenuates Inflammation and Injury of Intestinal Epithelial Cells upon EnterotoxigenicInternational journal of molecular sciences · 2025Article
- Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024Review
- Characterising glycosaminoglycans in human breastmilk and their potential role in infant health.Microbial cell (Graz, Austria) · 2024Article
- Impact of neonatal nutrition on necrotizing enterocolitis.Seminars in pediatric surgery · 2023Review
- Human milk glycosaminoglycans inhibit cytomegalovirus and respiratory syncytial virus infectivity by impairing cell binding.Pediatric research · 2022Article
- The Life-Long Role of Nutrition on the Gut Microbiome and Gastrointestinal Disease.Gastroenterology clinics of North America · 2021Review
- Prevalence, Clinical Characteristics and Changes of Antibiotic Resistance in Children with NontyphoidalInfection and drug resistance · 2021Article
- Article
- Anti-Zika virus and anti-Usutu virus activity of human milk and its components.PLoS neglected tropical diseases · 2020Article
- Non-typhoidal Salmonella infections among children in a tertiary hospital in Ningbo, Zhejiang, China, 2012-2019.PLoS neglected tropical diseases · 2020Article
- The Protective Effects of 2'-Fucosyllactose againstNutrients · 2020Article
- The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review.Nutrients · 2020Review
- The Protective Influence of Chondroitin Sulfate, a Component of Human Milk, on Intestinal Bacterial Invasion and Translocation.Journal of human lactation : official journal of International Lactation Consultant Association · 2019Article
- Utilization of Host-Derived Glycans by IntestinalFrontiers in microbiology · 2018Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast-fed infants have a lower incidence of acute gastroenteritis due to the presence of several anti-infective factors in human milk. The aim of this work is to study the capacity of human milk glycosaminoglycans (GAGs) to inhibit the adhesion of some common pathogenic bacteria.
methodsGAGs were isolated from a pool of milk samples collected from different mothers during the first month of lactation. Experiments were carried out to study the ability of GAGs to inhibit the adhesion of two intestinal micro-organisms (enteropathogenic Escherichia coli serotype 0119 and Salmonella fyris) to Caco-2 and Int-407 cell lines.
resultsThe study showed that the GAGs had an anti-adhesive effect on the two pathogenic strains studied with different degrees of inhibition. In particular, in the presence of human milk GAGs, the adhesion of S. fyris to Caco-2 cells and to Int-407 cells of both tested strains was significantly reduced.
conclusionOur results demonstrated that GAGs in human milk can be one of the important defensive factors against acute diarrheal infections in breast-fed infants.
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Registered trials
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