ArticlePediatric research2016
Risk factors of different congenital heart defects in Guangdong, China.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- First trimester maternal infections and offspring congenital heart defects: a meta-analysis.European heart journal · 2026Pooled it
- Pooled it
- The non-genetic paternal factors for congenital heart defects: A systematic review and meta-analysis.Clinical cardiology · 2019Pooled it
- The influence of paternal preconception health on birth defects and head circumference: A scoping review.PLOS global public health · 2026Article
- Lower Socioeconomic Status is Associated with an Increased Incidence and Spectrum of Major Congenital Heart Disease and Associated Extracardiac Pathology.Pediatric cardiology · 2024Article
- Spectrum of Heart Diseases in Children in a National Cardiac Referral Center Tanzania, Eastern Africa: A Six-Year Overview.Global heart · 2024Observational
- Perinatal deaths attributable to congenital heart defects in Hunan Province, China, 2016-2020.PloS one · 2024Article
- Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter.Birth defects research · 2023Review
- Reducing the Risk of Birth Defects Associated with Maternal Influenza: Insights from a Hungarian Case-Control Study.Journal of clinical medicine · 2023Article
- Maternal periconceptional environmental exposure and offspring with congenital heart disease: a case-control study in Guangzhou, China.BMC pregnancy and childbirth · 2023Article
- Risk of maternal exposure to mixed air pollutants during pregnancy for congenital heart diseases in offspring.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- Prenatal Detection of Congenital Heart Diseases Using Echocardiography: 12-Year Results of an Improving Program With 9782 Cases.Frontiers in public health · 2022Article
- Associations between ambient heat exposure early in pregnancy and risk of congenital heart defects: a large population-based study.Environmental science and pollution research international · 2022Article
- Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis.Asian biomedicine : research, reviews and news · 2021Article
- Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population.BMC pregnancy and childbirth · 2021Article
- Anything New about Paternal Contribution to Reproductive Outcomes? A Review of the Evidence.The world journal of men's health · 2021Review
- First-Trimester Maternal Folic Acid Supplementation Modifies the Effects of Risk Factors Exposures on Congenital Heart Disease in Offspring.Life (Basel, Switzerland) · 2021Article
- Parental occupational exposure and congenital heart diseases in a Hungarian case-control study.International archives of occupational and environmental health · 2021Article
- Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach.PLoS genetics · 2021Article
- Neighbourhood maternal socioeconomic status indicators and risk of congenital heart disease.BMC pregnancy and childbirth · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited studies have evaluated the risk factors for congenital heart defects (CHDs) in China and compared them for different types of CHDs. This study examined risk factors between isolated and multiple CHDs as well as among CHDs subtypes in Guangdong, Southern China.
methodsThis population-based case-control study included 4,034 pairs of case and control infants enrolled in the Guangdong Registry of CHD study, 2004-2013. Multivariate logistic regression was used to compute adjusted odds ratios (ORs) while simultaneously controlling for confounders.
resultsMultiple maternal environmental exposures, including living in newly renovated rooms, residential proximity to main traffic, paternal smoking, and maternal occupation as manual worker, were significantly associated with CHDs with ORs ranging 1.30-9.43. Maternal perinatal diseases (including maternal fever, diabetes, influenza, and threatened abortion), maternal medication use (antibiotic use), advanced maternal age, low socioeconomic status, and paternal alcohol intake were also significantly associated with CHDs, with ORs ranging 1.60-3.96. Isolated CHDs and multiple defects have different profiles of risk factors, while subtype of CHD shares common risk factors.
conclusionThese results suggest that maternal environmental exposures/occupation and perinatal diseases/medication use were dominant risk factors associated with CHDs in Southern China. Isolated and multiple CHDs may have different etiologic factors.
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