ArticlePediatric research2016
The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Three-dimensional imaging reveals a hierarchical organisation of the myocardial mesh in mammalian hearts.Scientific reports · 2026Article
- A Proof of Principle 2D Spatial Proteome Mapping Analysis Reveals Distinct Regional Differences in the Cardiac Proteome.Life (Basel, Switzerland) · 2024Article
- Impact of intraventricular septal fiber orientation on cardiac electromechanical function.American journal of physiology. Heart and circulatory physiology · 2022Article
- Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload.Frontiers in physiology · 2022Review
- Exploring arterial tissue microstructural organization using non-Gaussian diffusion magnetic resonance schemes.Scientific reports · 2021Article
- Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension.Intensive care medicine experimental · 2021Article
- Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.Frontiers in physiology · 2021Review
- Assessing Myocardial Architecture: The Challenges and Controversies.Journal of cardiovascular development and disease · 2020Review
- Cardiac multi-scale investigation of the right and left ventricleCardiovascular diagnosis and therapy · 2020Review
- Magnetic resonance hyperpolarization imaging detects early myocardial dysfunction in a porcine model of right ventricular heart failure.European heart journal. Cardiovascular Imaging · 2020Article
- Resolving the natural myocardial remodelling brought upon by cardiac contraction; a porcine ex-vivo cardiovascular magnetic resonance study of the left and right ventricle.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Resolving the True Ventricular Mural Architecture.Journal of cardiovascular development and disease · 2018Review
- Changes in overall ventricular myocardial architecture in the setting of a porcine animal model of right ventricular dilation.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- Ventricular myocardium development and the role of connexins in the human fetal heart.Scientific reports · 2017Article
- The human fetal right ventricular myocardium appears without a sub-epicardial base-apex oriented layer of myocytes.Pediatric research · 2017Article
- Heart structural remodeling in a mouse model of Duchenne cardiomyopathy revealed using optical polarization tractography [Invited].Biomedical optics express · 2017Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPersistent pulmonary hypertension in the newborn remains a syndrome with high mortality. Knowledge of changes in myocardial architecture in the setting of heart failure in persistent pulmonary hypertension is lacking, and could aid in the explanation of the prevailing high mortality.
methodsPersistent pulmonary hypertension was induced by antenatal ligation of the arterial duct in six ovine fetuses. The hearts were compared ex vivo with five matched control hearts, using diffusion tensor imaging to provide the overall anatomical arrangement, and assessment of the angulations and course of the cardiomyocytes. Fibrosis was assessed with histology.
resultsWe found an overall increase in heart size in pulmonary hypertension, with myocardial thickening confined to the interventricular septum. An increase of 3.5° in angulation of myocyte aggregations was found in hypertensive hearts. In addition, we observed a 2.2% increase in collagen content in the right ventricular free wall. Finally, we found a previously undescribed subepicardial layer of strictly longitudinally oriented cardiomyocytes confined to the right ventricle in all hearts.
conclusionMyocardial fibrosis and possibly changes in angulations of myocytes seem to play a part in the etiology of persistent pulmonary hypertension. Moreover, a new anatomical arrangement of right ventricular mural architecture is described.
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