Evidence map›Paper›PMID 26679097›Full record

ArticleHuman brain mapping2016

In vivo MRI signatures of hippocampal subfield pathology in intractable epilepsy.

Maged Goubran, Boris C Bernhardt, Diego Cantor-Rivera, Jonathan C Lau, Charlotte Blinston, Robert R Hammond, Sandrine de Ribaupierre, Jorge G Burneo, Seyed M Mirsattari, David A Steven and 5 more

Open access · bronzeAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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  13. Combined quantitative T2 mapping and [European radiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Maged GoubranImaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
Boris C BernhardtNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Diego Cantor-RiveraImaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
Jonathan C LauDepartment of Clinical Neurological Sciences, Epilepsy Program, Western University, London, Ontario, Canada.
Charlotte BlinstonImaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
Robert R HammondDepartment of Pathology, Division of Neuropathology, London, Ontario, Canada.
Sandrine de RibaupierreBiomedical Engineering Graduate Program, Western University, London, Ontario, Canada.
Jorge G BurneoDepartment of Clinical Neurological Sciences, Epilepsy Program, Western University, London, Ontario, Canada.
Seyed M MirsattariDepartment of Clinical Neurological Sciences, Epilepsy Program, Western University, London, Ontario, Canada.
David A StevenDepartment of Clinical Neurological Sciences, Epilepsy Program, Western University, London, Ontario, Canada.
Andrew G ParrentDepartment of Clinical Neurological Sciences, Epilepsy Program, Western University, London, Ontario, Canada.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Neda BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Terry M PetersImaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
Ali R KhanDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Western University · CAMontreal Neurological Institute and Hospital · CARobarts Clinical Trials · CALondon Health Sciences Centre · CAMcGill University · CA

Funding

Canadian Institutes of Health Research MOP 184807
6 · The paper itself

Abstract

objectivesOur aim is to assess the subfield-specific histopathological correlates of hippocampal volume and intensity changes (T1, T2) as well as diff!usion MRI markers in TLE, and investigate the efficacy of quantitative MRI measures in predicting histopathology in vivo. EXPERIMENTAL

designWe correlated in vivo volumetry, T2 signal, quantitative T1 mapping, as well as diffusion MRI parameters with histological features of hippocampal sclerosis in a subfield-specific manner. We made use of on an advanced co-registration pipeline that provided a seamless integration of preoperative 3 T MRI with postoperative histopathological data, on which metrics of cell loss and gliosis were quantitatively assessed in CA1, CA2/3, and CA4/DG. PRINCIPAL OBSERVATIONS: MRI volumes across all subfields were positively correlated with neuronal density and size. Higher T2 intensity related to increased GFAP fraction in CA1, while quantitative T1 and diffusion MRI parameters showed negative correlations with neuronal density in CA4 and DG. Multiple linear regression analysis revealed that in vivo multiparametric MRI can predict neuronal loss in all the analyzed subfields with up to 90% accuracy.

conclusionOur results, based on an accurate co-registration pipeline and a subfield-specific analysis of MRI and histology, demonstrate the potential of MRI volumetry, diffusion, and quantitative T1 as accurate in vivo biomarkers of hippocampal pathology.

Indexed as

AdultCell CountCohort StudiesDiffusion Tensor ImagingDrug Resistant EpilepsyFemaleHippocampusHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedNeuronsOrgan SizeReproducibility of ResultsDTIhippocampal sclerosishippocampal subfieldshistologyMRItemporal lobe epilepsyvolumetry

Identifiers

PMID26679097
PMCPMC6867266
OpenAlexW2205858405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.