ArticlePloS one2015
Mono-Exponential Fitting in T2-Relaxometry: Relevance of Offset and First Echo.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
- Quantifying disease activity in fatty-infiltrated skeletal muscle by IDEAL-CPMG in Duchenne muscular dystrophy.Neuromuscular disorders : NMD · 2016Trial
- Effects of Postmortem Intervals on Quantitative MRI in Unfixed and Fixed Swine Brain: Implications for Ex Vivo MRI Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Assessing the Impact of Imaging Parameters on MRI Measurement of Kidney TJournal of magnetic resonance imaging : JMRI · 2026Article
- Evaluation of end-to-end 3D absorbed dose distribution inEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Longitudinal MRI Characterization of TNMR in biomedicine · 2026Article
- MRI-T2 Relaxometry is Increased in Mild Traumatic Brain Injury: Indications of Acute Brain Abnormalities After Injury.Journal of neuroscience research · 2025Article
- HDNLS: Hybrid Deep-Learning and Non-Linear Least Squares-Based Method for Fast Multi-Component T1ρ Mapping in the Knee Joint.Bioengineering (Basel, Switzerland) · 2024Article
- Unveiling the Exquisite Microstructural Details in Zebrafish Brain Non-Invasively Using Magnetic Resonance Imaging at 28.2 T.Molecules (Basel, Switzerland) · 2024Article
- Validation of quantitative magnetic resonance imaging techniques in head and neck healthy structures involved in the salivary and swallowing function: Accuracy and repeatability.Physics and imaging in radiation oncology · 2024Article
- Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review.The neuroradiology journal · 2024Review
- Longitudinal analysis of T2 relaxation time variations following radiotherapy for prostate cancer.Heliyon · 2024Article
- Evolution of peripheral nerve changes in early multiple sclerosis-a longitudinal MR neurography study.Frontiers in neurology · 2024Article
- Individual-level analysis of MRI T2 relaxometry in mild traumatic brain injury: Possible indications of brain inflammation.NeuroImage. Clinical · 2024Article
- Perfusion of MC3T3E1 Preosteoblast Spheroids within Polysaccharide-Based Hydrogel Scaffolds: An Experimental and Numerical Study at the Bioreactor Scale.Bioengineering (Basel, Switzerland) · 2023Article
- Quantification and Proximal-to-Distal Distribution Pattern of Tibial Nerve Lesions in Relapsing-Remitting Multiple Sclerosis : Assessment by MR Neurography.Clinical neuroradiology · 2023Article
- Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis.Diagnostics (Basel, Switzerland) · 2023Article
- Additively manufactured, solid object structures for adjustable image contrast in Magnetic Resonance Imaging.Zeitschrift fur medizinische Physik · 2022Article
- Simultaneous high-resolution TMagnetic resonance in medicine · 2022Article
- Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2022Article
- Quantitative assessment of normal hip cartilage in children under 9 years old by T2 mapping.Magma (New York, N.Y.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionT2 relaxometry has become an important tool in quantitative MRI. Little focus has been put on the effect of the refocusing flip angle upon the offset parameter, which was introduced to account for a signal floor due to noise or to long T2 components. The aim of this study was to show that B1 imperfections contribute significantly to the offset. We further introduce a simple method to reduce the systematic error in T2 by discarding the first echo and using the offset fitting approach. MATERIALS AND
methodsSignal curves of T2 relaxometry were simulated based on extended phase graph theory and evaluated for 4 different methods (inclusion and exclusion of the first echo, while fitting with and without the offset). We further performed T2 relaxometry in a phantom at 9.4T magnetic resonance imaging scanner and used the same methods for post-processing as in the extended phase graph simulated data. Single spin echo sequences were used to determine the correct T2 time.
resultsThe simulation data showed that the systematic error in T2 and the offset depends on the refocusing pulse, the echo spacing and the echo train length. The systematic error could be reduced by discarding the first echo. Further reduction of the systematic T2 error was reached by using the offset as fitting parameter. The phantom experiments confirmed these findings.
conclusionThe fitted offset parameter in T2 relaxometry is influenced by imperfect refocusing pulses. Using the offset as a fitting parameter and discarding the first echo is a fast and easy method to minimize the error in T2, particularly for low to intermediate echo train length.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.