ArticleBMC geriatrics2015
Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS).
Article in BMC geriatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of sarcopenia in COPD patients using AWGS criteria among Asian populations: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Article
- Neuromuscular impairment at different stages of human sarcopenia.Journal of cachexia, sarcopenia and muscle · 2024Article
- Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2023Article
- DEHP exposure impairs human skeletal muscle cell proliferation in primary culture conditions: preliminary study.Cytotechnology · 2023Article
- Sarcopenia and Frailty: Challenges in Mainstream Nephrology Practice.Kidney international reports · 2021Review
- The role of novel motor unit magnetic resonance imaging to investigate motor unit activity in ageing skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2021Review
- Feasibility, Efficacy, and Safety of Percutaneous Muscle Biopsies in Patients With Chronic Liver Disease.Frontiers in physiology · 2021Article
- Sarcopenia Characteristics Are Associated with Incident Mobility Limitations in African Caribbean Men: The Tobago Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2018Article
- The Microvasculature and Skeletal Muscle Health in Aging.Exercise and sport sciences reviews · 2018Review
- Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS).Calcified tissue international · 2018Article
- Predicting mortality and incident immobility in older Belgian men by characteristics related to sarcopenia and frailty.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Appendicular Skeletal Muscle Mass Reference Values and the Peak Muscle Mass to Identify Sarcopenia among Iranian Healthy Population.International journal of preventive medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men.
methodsOne hundred and five men aged 68-76 years were recruited to the Hertfordshire Sarcopenia Study (HSS) for detailed characterisation of muscle including measures of muscle mass, strength and function. Muscle tissue was obtained from a biopsy of the vastus lateralis for 99 men and was processed for immunohistochemical studies to determine myofibre distribution and area, capillarisation and satellite cell (SC) density.
resultsSix (6 %) men had sarcopenia as defined by the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. These men had lower SC density (1.7 cells/mm(2) vs 3.8 cells/mm(2), p = 0.06) and lower SC/fibre ratio (0.02 vs 0.06, p = 0.06) than men without sarcopenia. Although men with sarcopenia tended to have smaller myofibres and lower capillary to fibre ratio, these relationships were not statistically significant.
conclusionWe have shown that there may be altered muscle morphology parameters in older men with sarcopenia. These results have the potential to help identify cell and molecular targets for therapeutic intervention. This work now requires extension to larger studies which also include women.
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